Wei Wu, PhD, Eugene Bleecker, MD, Wendy Moore, MD, William W

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Presentation transcript:

Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data Wei Wu, PhD, Eugene Bleecker, MD, Wendy Moore, MD, William W. Busse, MD, Mario Castro, MD, Kian Fan Chung, MD, William J. Calhoun, MD, Serpil Erzurum, MD, Benjamin Gaston, MD, Elliot Israel, MD, Douglas Curran-Everett, PhD, Sally E. Wenzel, MD Journal of Allergy and Clinical Immunology Volume 133, Issue 5, Pages 1280-1288 (May 2014) DOI: 10.1016/j.jaci.2013.11.042 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Asthma symptom and quality-of-life variables differed by subject clusters. Cluster 6 had the highest shortness of breath frequency (A), the highest cough frequency (B), and the lowest AQLQ activity limitation score (C) among all clusters. The intergroup differences for all variables can be found in Table E3. Journal of Allergy and Clinical Immunology 2014 133, 1280-1288DOI: (10.1016/j.jaci.2013.11.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Age of asthma onset and allergy differed by subject clusters according to asthma disease status. A and B, Cluster 5 had later onset (Fig 2, A) and lower numbers of allergen-induced skin reactions (Fig 2, B) than all other clusters. C, Cluster 2 had less allergy symptoms in winter than clusters 4 to 6. D, Clusters 2 to 6 have more asthma symptoms caused by animal exposure than cluster 1. Journal of Allergy and Clinical Immunology 2014 133, 1280-1288DOI: (10.1016/j.jaci.2013.11.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 HCU differed by subject clusters. A, Subjects in clusters 3 to 6 were more likely to have seen a doctor in the last 12 months for asthma than those in cluster 2. B and C, Cluster 6 had a higher proportion of subjects who visited the emergency department (ER) for breathing in the last year (Fig 3, B) and number of intensive care unit (ICU) admissions for asthma (Fig 3, C) than all other clusters. Journal of Allergy and Clinical Immunology 2014 133, 1280-1288DOI: (10.1016/j.jaci.2013.11.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Corticosteroid (CS) use, treatment consequences, and associated clinical characteristics differ across subject clusters. A-C, Cluster 6 had the higher proportion of subjects with more than 3 oral corticosteroid bursts in the previous year (Fig 4, A), receiving oral corticosteroids (Fig 4, B), and having osteoporosis (Fig 3, C) than all other asthma clusters. D and E, Cluster 5 had the highest proportion of subjects with nasal polyps removed (Fig 4, D) and with sinusitis (Fig 4, E). Journal of Allergy and Clinical Immunology 2014 133, 1280-1288DOI: (10.1016/j.jaci.2013.11.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Airway responsiveness and TH2 inflammatory markers differ across subject clusters. A, Prebronchodilator FEV1/forced vital capacity (FVC) ratio was lower in cluster 6 than in all other clusters. B, There were no differences in reversibility across asthma clusters. C, Cluster 6 had higher Feno values compared with all other clusters. D, Clusters 2, 4, and 5 had higher blood eosinophil counts than cluster 1. Journal of Allergy and Clinical Immunology 2014 133, 1280-1288DOI: (10.1016/j.jaci.2013.11.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology 2014 133, 1280-1288DOI: (10.1016/j.jaci.2013.11.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Journal of Allergy and Clinical Immunology 2014 133, 1280-1288DOI: (10.1016/j.jaci.2013.11.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Journal of Allergy and Clinical Immunology 2014 133, 1280-1288DOI: (10.1016/j.jaci.2013.11.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Journal of Allergy and Clinical Immunology 2014 133, 1280-1288DOI: (10.1016/j.jaci.2013.11.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E6 Journal of Allergy and Clinical Immunology 2014 133, 1280-1288DOI: (10.1016/j.jaci.2013.11.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions