Learning the ABCs of Melanoma-Initiating Cells

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells Nilay Sethi, Xudong Dai, Christopher.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Ablation of Fbxw7 Eliminates Leukemia-Initiating Cells by Preventing Quiescence Shoichiro Takeishi, Akinobu Matsumoto, Ichiro Onoyama, Kazuhito Naka, Atsushi.

PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment Yongping Crawford, Ian.

C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells Roger R. Gomis, Claudio Alarcón, Cristina Nadal, Catherine.

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib Ling Li, Lisheng Wang, Liang Li, Zhiqiang.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells David J. Wong, Helen Liu, Todd W. Ridky, David Cassarino, Eran Segal, Howard.

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity Cai-Hong.

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung Zvi Granot, Erik Henke, Elizabeth A. Comen, Tari A. King, Larry Norton, Robert Benezra.

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

A Conditional Mouse Model for Malignant Mesothelioma Johan Jongsma, Erwin van Montfort, Marc Vooijs, John Zevenhoven, Paul Krimpenfort, Martin van der.

A Conditional Mouse Model of Synovial Sarcoma: Insights into a Myogenic Origin Malay Haldar, Jeffrey D. Hancock, Cheryl M. Coffin, Stephen L. Lessnick,

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

Volume 1, Issue 1, Pages (June 2007)

The Metastasis Problem Gets Stickier

Cell Cycle Rules Pluripotency

Adipocytes at the Core of Bone Function

Sox2: Masterminding the Root of Cancer

A Sweet New Role for EGFR in Cancer

Annapoorni Rangarajan, Sue J. Hong, Annie Gifford, Robert A. Weinberg

MDS Is a Stem Cell Disorder After All

DAISY: Picking Synthetic Lethals from Cancer Genomes

Volume 26, Issue 1, Pages 1-2 (July 2014)

Fingered for a Fat Fate Cell Metabolism

Eun-Jung Jung, George A. Calin Cancer Cell

The Wind God Promotes Lung Cancer

Wing Y. Chang, William L. Stanford Cell Stem Cell

CALming Down T Cell Acute Leukemia

MicroRNA Regulation of Stem Cell Fate

Hopping between Differentiation States in Lung Adenocarcinoma

Learning the ABCs of Melanoma-Initiating Cells

MicroRNAs and Parallel Stem Cell Lives

Considering the critical interface between tumor cells and stromal cells in the search for targets for anticancer therapy Laurence Blavier, Yves A. DeClerck

Mapping Cancer Origins

From Cancer Stem Cells to Tumor Maintenance in Melanoma

Bmi1 and Cell of Origin Determinants of Brain Tumor Phenotype

Mizuho Fukunaga-Kalabis, Meenhard Herlyn

KIT in Melanoma: Many Shades of Gray

Volume 14, Issue 4, Pages (October 2008)

To Infinium, and Beyond! Cancer Cell

The Side Story of Stem-like Glioma Cells

Volume 10, Issue 3, Pages (September 2006)

Guillermo A. Orsi, Monica Naughtin, Geneviève Almouzni Cell Stem Cell

Chapter 29 - Stem Cells and Generation of New Cells in the

Tracy-Ann Read, Robert J. Wechsler-Reya Cancer Cell

Searching for leukemia stem cells—Not yet the end of the road?

There's a Time and a Place for MYCN

Volume 13, Issue 4, Pages (April 2008)

Volume 12, Issue 6, Pages (December 2007)

The Role of TET2 in Hematologic Neoplasms

Presentation transcript:

Learning the ABCs of Melanoma-Initiating Cells Susan E. Zabierowski, Meenhard Herlyn Cancer Cell Volume 13, Issue 3, Pages 185-187 (March 2008) DOI: 10.1016/j.ccr.2008.02.015 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 ABCB5 Expression in a Melanoma Stem Cell Hierarchy In the cancer stem cell hierarchy of melanoma, ABCB5+ melanoma-initiating cells give rise to more committed progenitor/transamplifying cells that may or may not express ABCB5, depending on the stage of differentiation, while terminally differentiated cells lack expression of ABCB5. Tumorigenic potential is lost as these cells proceed toward differentiation as well as chemoresistance due to the downmodulation of ABCB5, a doxorubicin efflux transporter. Cancer Cell 2008 13, 185-187DOI: (10.1016/j.ccr.2008.02.015) Copyright © 2008 Elsevier Inc. Terms and Conditions