Progress Seminar 2018.10.23 권순빈.

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Progress Seminar 2018.10.23 권순빈

연구 진행 상황 보고서 2주전 계획 연구 결과 문제점 및 대책 목표 및 계획 CPF 정형외과 낙상 혈당센서 논문 제출 IRB 논문 초안 요청사항 완료 문제점 및 대책 목표 및 계획

Mechanism of Electrical Stimulation for pain relief Pain Mechanism : A New Theory Gate Control Theory Melzack and Wall in 1965 McGill & MIT; Science A gate control system modulates sensory input from the skin before it evokes pain perception and response

Mechanism of Electrical Stimulation for pain relief There are three types of nerve fibers  A, B, C Four subgroups of A fibers  A-alpha, A-beta, A-gamma and A-delta A-delta and C  smaller & carries pain Other A fibers  larger & carries pressure, temperature, touch, etc. Pain pathway A-delta & C fibers are activated Go through spinal cord and to the brain  But this is not true!

Mechanism of Electrical Stimulation for pain relief There is a gate control system at the spinal cord Substantia gelatinosa (SG) determines which signal to reach the T cells L (Large fibers) and S (Small fibers) If ‘S’ < ‘L’ SG prevents the transmission of the pain to T cells Other sensory signal override the pain signal Pain signal is not reached to the brain  If ‘S’ > ‘L’ Pain signal transmitted to T cell and to the brain Descending signal from CNS also affects the decision of the gate

Mechanism of Electrical Stimulation for pain relief Transcutaneous Electric Nerve Stimulation (TENS) Segmental (Stimulating the ‘L’ fibers ) Only large-diameter primary afferent fibers from deep tissue are activated at sensory intensities up to & including motor threshold Descending (Activates the adrenergic & opioids receptors) Mechanism not found yet Block specific receptor or pathway & sees the effect