The level of reactive oxygen species differentially regulates peroxiredoxin oxidation and mitogen-activated protein kinase signaling in human chondrocytes

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Presentation transcript:

The level of reactive oxygen species differentially regulates peroxiredoxin oxidation and mitogen-activated protein kinase signaling in human chondrocytes J.A. Collins, S.T. Wood, L. Poole, C. Furdui, R. Loeser Osteoarthritis and Cartilage Volume 24, Pages S179-S180 (April 2016) DOI: 10.1016/j.joca.2016.01.354 Copyright © 2016 Terms and Conditions

Figure 1. Effect of menadione and FN-f on chondrocyte PRX oxidation Figure 1. Effect of menadione and FN-f on chondrocyte PRX oxidation. Normal human articular chondrocytes were exposed to menadione (25 μM) or FN-f (1 μM) for 0–60 minutes and PRX oxidation was evaluated. Immunoblots shown are representative of three independent experiments. RM = reduced monomer; HM = hyperoxidized monomer. Data is presented as mean ± SEM of n = 3 independent experiments, *P = <0.05. Osteoarthritis and Cartilage 2016 24, S179-S180DOI: (10.1016/j.joca.2016.01.354) Copyright © 2016 Terms and Conditions