Gene Profiling of Keloid Fibroblasts Shows Altered Expression in Multiple Fibrosis- Associated Pathways  Joan C. Smith, Braden E. Boone, Susan R. Opalenik, Scott M. Williams, Shirley B. Russell  Journal of Investigative Dermatology  Volume 128, Issue 5, Pages 1298-1310 (May 2008) DOI: 10.1038/sj.jid.5701149 Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Unsupervised hierarchical clustering analysis of normal and keloid fibroblasts grown with and without HC. Unsupervised hierarchical clustering was performed on 19 samples of normal and keloid fibroblasts grown with and without HC, using a subset of genes (n=7303) whose expression varied by at least twofold relative to the average normal strain in at least two of the 19 samples. Gene expression of cell strains grown in medium with and without (control) 1.5μM HC supplementation fell into four distinguishable groups relative to gene expression in the average normal strain grown in control medium. From right to left are five normal strains in control medium, four normal strains with HC (one strain lost in processing), five keloid strains in control medium, five keloid strains with HC. Red indicates increased expression, blue indicates reduced expression, and yellow indicates no difference in expression. Journal of Investigative Dermatology 2008 128, 1298-1310DOI: (10.1038/sj.jid.5701149) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions