Cell migration is mediated by Rho-GTPase protein activity.

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Presentation transcript:

Cell migration is mediated by Rho-GTPase protein activity. Cell migration is mediated by Rho-GTPase protein activity. Cell polarity is mediated by Cdc42 activity. Membrane protrusions are formed and are dependent on Rac1 (lamellipodia) and Cdc42 (filopodia) activity. Membrane protrusions grip the extracellular matrix via RhoA-dependent focal adhesion (FA) formation and actomyosin contraction pulls the cell forward via RhoA effector protein Rho-associated kinase (ROCK)-mediated phosphorylation of myosin light chain kinase. Disassembly of focal adhesion and tail retraction is also mediated by RhoA activity. ECM: extracellular matrix. Fraser R. Millar et al. Eur Respir Rev 2017;26:160069 ©2017 by European Respiratory Society