Molecular surface models of the active-site cleft of the OXA-51-like enzymes. Molecular surface models of the active-site cleft of the OXA-51-like enzymes.

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Molecular surface models of the active-site cleft of the OXA-51-like enzymes. Molecular surface models of the active-site cleft of the OXA-51-like enzymes. Structural models were created by using the online protein homology/analogy recognition engine (phyre) (http://www.sbg.bio.ic.ac.uk/∼phyre/), using the crystal structure for OXA-40/24 reported by Santillana et al. (38) as a backbone. Using local numbering, structures were viewed in Swiss-PdbViewer DeepView version 4 (http://spdbv.vital-it.ch/). (A) View down the active-site cleft of OXA-66 with the active-site serine 80 (red) and an isoleucine at position 129 (blue); (B) view down the active-site cleft of OXA-83 with the active-site serine 80 (red) and a leucine at position 129 (blue); (C) view down the active-site cleft of OXA-66 (from the opposite orientation to panels A and B) with the active-site serine 80 (red) and a leucine at position 167 (blue); (D) view down the active-site cleft of OXA-82 with the active-site serine 80 (red) and a valine at position 167 (blue). Benjamin A. Evans, and Sebastian G. B. Amyes Clin. Microbiol. Rev. 2014; doi:10.1128/CMR.00117-13