Fig. 3 Responsiveness to alterations in other one-carbon nutrient availability is largely MTAP status independent. Responsiveness to alterations in other.

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Fig. 3 Responsiveness to alterations in other one-carbon nutrient availability is largely MTAP status independent. Responsiveness to alterations in other one-carbon nutrient availability is largely MTAP status independent. (A) Validation of serine and cysteine restriction. (B) Heat map of fold changes in global metabolite levels upon serine (left) and cysteine (right) restriction, hierarchically clustered by cell lines and metabolites. Top affected pathways are indicated. (C) Fold change values of MTA metabolite levels either in complete (280 μM Ser, or Ser+, and 200 μM Cys, or Cys+) or restricted (~16 μM Ser, or Ser−, and 6 μM Cys, or Cys−) medium. (D) Volcano plot of fold change (Ser−/Ser+ or Cys−/Cys+) values of metabolites, averaged across either MTAP+/+ or MTAP−/− groups. P values obtained using Student’s t test. GSSG, oxidized glutathione; CMP, cytidine 5′-monophosphate. (E) Fraction of significantly altered (P < 0.05, Student’s t test) metabolites that are related (i.e., within five reactions) or unrelated to serine (left) and cysteine (right). (F) Alterations in relative metabolite levels upon cysteine restriction in metabolites involved in taurine biosynthesis. Sydney M. Sanderson et al. Sci Adv 2019;5:eaav7769 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).