Distribution of podocyte gene mutations in patients with genetic congenital nephrotic syndrome (CNS) and steroid–resistant nephrotic syndrome (SRNS). Distribution.

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Distribution of podocyte gene mutations in patients with genetic congenital nephrotic syndrome (CNS) and steroid–resistant nephrotic syndrome (SRNS). Distribution of podocyte gene mutations in patients with genetic congenital nephrotic syndrome (CNS) and steroid–resistant nephrotic syndrome (SRNS). (A) Gene mutations in the total study cohort of patients with genetic disease (n=131). 85% of mutations were identified in NPHS1, NPHS2, and WT1. All other gene mutations were rare events affecting a small number of patients. (B) Distribution of podocyte gene mutations in patients with genetic CNS (left panel; n=60) and genetic SRNS (right panel; n=71). Anja K. Büscher et al. CJASN 2016;11:245-253 ©2016 by American Society of Nephrology