Big Q: How can we use genetics to study human inheritance? Human Heredity Big Q: How can we use genetics to study human inheritance?

Engage - Untamed Science Why is colorblindness more likely to affect men than women? What does it mean to be sex-linked?

Explain - Karyotypes Karyotype - shows the complete diploid set of chromosomes grouped together in pairs and arranged in order of decreasing size. Shows: 1. Autosomes - body chromosomes (22 pairs) 2. Sex Chromosomes - X and Y (1 pair) genome - a full set of genetic information

Explore - Multiple Alleles Look at the chart and explain how individuals are able to have more than one gene for a trait. contain antigens: A - antigen A B - antigen B AB - antigens AB O - no antigens

Explain - Sex Linked Sex-Linked Genes - can only be carried on sex chromosomes

Elaborate - How is Color Blindness transmitted? Investigate how genes are transmitted when they are sex linked. ****Answer all questions on your quick lab worksheet

Explain - Human Pedigree Pedigree Chart - shows the presence or absence of a trait throughout a family history

Explore - Genetic Disorders Cystic Fibrosis - deletion of three bases for the CFTR protein preventing the lungs from absorbing chlorine ions. Symptoms - serious digestive problems and thick heavy mucus that clogs breathing passageways

Explain - Genetic Disorders Sickle Cell Disease - defective allele for beta-globin preventing normal carry of red blood cells Symptoms - abnormal shape or number of blood cells, blood clots, difficulty breathing, lack of energy, iron deficiency

Elaborate - Malaria Study Investigate the geography of malaria to see how this disease is affected by sickle cell anemia ***Answer questions on your Quick Lab Worksheet

Explain - Genetic Disorders Huntington’s Disease - a long repeat of three base pairs causes a protein in the brain to form incorrectly Symptoms - mental deterioration and uncontrollable movements

Explain - genetic Disorders Nondisjunction - chromosomes do not separate correctly during meiosis Types: 1. Down Syndrome - Trisomy 21, three copies 2. Klinefelter’s Syndrome - XXY 3. Turner Syndrom - X

Explain - Studying DNA Cutting DNA - restriction enzymes can make precise cuts in DNA Separating DNA - gel electrophoresis separates DNA based on size

Evaluate - Genetic Disorders Research and create an information pamphlet about a genetic disorder. 1. Sickle Cell Anemia 2. Hemophilia 3. Cystic Fibrosis 4. Huntington’s Disease 5. ALS Disease 6. PKU 7. Tourette’s Syndrome 8. Muscular Dystrophy 9. Retinitis Pigmentosa 10. Tay Sach’s Diseas 11. Fragile X Syndrome 12. Angelman Syndrome 13. Patau’s Syndrome 14. Edward Syndrome Include: Type of mutation Symptoms Complications Description of mutation