Improved Early Outcomes Using a T Cell Replete Graft Compared with T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation Stefan O. Ciurea,

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Presentation transcript:

Improved Early Outcomes Using a T Cell Replete Graft Compared with T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation Stefan O. Ciurea, Victor Mulanovich, Rima M. Saliba, Ulas D. Bayraktar, Ying Jiang, Roland Bassett, Sa A. Wang, Marina Konopleva, Marcelo Fernandez-Vina, Nivia Montes, Doyle Bosque, Julianne Chen, Gabriela Rondon, Gheath Alatrash, Amin Alousi, Qaiser Bashir, Martin Korbling, Muzaffar Qazilbash, Simrit Parmar, Elizabeth Shpall, Yago Nieto, Chitra Hosing, Partow Kebriaei, Issa Khouri, Uday Popat, Marcos de Lima, Richard E. Champlin Biology of Blood and Marrow Transplantation Volume 18, Issue 12, Pages 1835-1844 (December 2012) DOI: 10.1016/j.bbmt.2012.07.003 Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Outcomes of T cell replete (TCR) and T cell depleted (TCD) haploidentical transplant patients treated with fludarabine, melphalan, and thiotepa conditioning. (A) Progression-free survival for all patients. (B) Progression-free survival for patients in remission at transplantation. (C) Non-relapse mortality for all patients. (D) Non-relapse mortality for patients in remission at transplantation. (E) Cumulative incidence of chronic graft-versus-host disease (cGVHD). (F) Cumulative incidence of grade II-IV acute graft-versus-host disease (aGVHD). Biology of Blood and Marrow Transplantation 2012 18, 1835-1844DOI: (10.1016/j.bbmt.2012.07.003) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Recovery of T cell subsets after transplant in T cell replete (TCR) and T cell depleted (TCD) haploidentical stem cell transplantations. **P < .002 (with Bonferroni correction); *P > .002 < .05. (A) Recovery of absolute CD8+ cell numbers (median). (B) Recovery of absolute CD4+ cell numbers (median). (C) Recovery of absolute CD4+CD45RA+ cell numbers (naive T cells) (median). (D) Recovery of absolute CD4+CD45RO+ cell numbers (memory T cells) (median). (E) Recovery of absolute CD56+ cell numbers (natural killer [NK] cells) (median). (F) Recovery of absolute CD19+ cell numbers (B cells) (median). Biology of Blood and Marrow Transplantation 2012 18, 1835-1844DOI: (10.1016/j.bbmt.2012.07.003) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions