Cardiac transplant coronary artery disease: A multivariable analysis of pretransplantation risk factors for disease development and morbid events David.

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Presentation transcript:

Cardiac transplant coronary artery disease: A multivariable analysis of pretransplantation risk factors for disease development and morbid events David C. McGiffin, MDa (by invitation), Timo Savunen, MDa (by invitation), James K. Kirklin, MDa, David C. Naftel, PhDa (by invitation), Robert C. Bourge, MDb (by invitation), Thomas D. Paine, MDb (by invitation), Connie White-Williams, RNa (by invitation), Tero Sisto, MDa (by invitation), Lesley Early, RNa (by invitation) The Journal of Thoracic and Cardiovascular Surgery Volume 109, Issue 6, Pages 1081-1089 (June 1995) DOI: 10.1016/S0022-5223(95)70191-5 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Actuarial (Kaplan-Meier) freedom from the angiographic (or autopsy) appearance of any cardiac transplant CAD (angiographic score greater than 0). Open circles represent actuarial appearance of CAD. The solid line represents the parametric estimate surrounded by the 70% confidence limits (dashed lines). UAB, University of Alabama at Birmingham. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1081-1089DOI: (10.1016/S0022-5223(95)70191-5) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Hazard function for the angiographic appearance of any cardiac transplant CAD, represented on the vertical axis as the number of patients per month in whom any CAD develops. It consists of a constant and a late phase. The hazard function (instantaneous risk) is represented by the solid line and is surrounded by the 70% confidence limits (dashed lines). UAB, University of Alabama at Birmingham. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1081-1089DOI: (10.1016/S0022-5223(95)70191-5) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Actuarial (Kaplan-Meier) freedom from the angiographic (or autopsy) appearance of any cardiac transplant CAD stratified by recipient gender. Circles, Female; squares, male. The error bars indicate 70% confidence limits. UAB, University of Alabama at Birmingham. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1081-1089DOI: (10.1016/S0022-5223(95)70191-5) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 Actuarial (Kaplan-Meier) freedom from the angiographic (or autopsy) appearance of any cardiac transplant CAD (angiographic score greater than 0) stratified by recipient pretransplantation CMV serologic status. Circles, negative; squares, positive. Error bars indicate 70% confidence limits. UAB, University of Alabama at Birmingham. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1081-1089DOI: (10.1016/S0022-5223(95)70191-5) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 5 Actuarial (Kaplan-Meier) freedom from angiographic (or autopsy) appearance of any cardiac transplant CAD stratified by donor age. Circles, less than 20 years; squares, 20 to 35 years; triangles, greater than 35 years. The error bars indicate 70% confidence limits. UAB, University of Alabama at Birmingham. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1081-1089DOI: (10.1016/S0022-5223(95)70191-5) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 6 Relationship between mean CAD score and increasing time from transplantation stratified by recipient gender. Circles, Male; squares, female. The error bars indicate 70% confidence limits. UAB, University of Alabama at Birmingham. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1081-1089DOI: (10.1016/S0022-5223(95)70191-5) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 7 Regression lines for rate of increase in mean CAD score according to the year of first angiographic detection of CAD. UAB, University of Alabama at Birmingham. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1081-1089DOI: (10.1016/S0022-5223(95)70191-5) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 8 Actuarial (Kaplan-Meier) and parametric freedom from a CAD event. Open circles indicate individual CAD events depicted actuarially. The solid line represents the parametric depiction with its 70% confidence limits. UAB, University of Alabama at Birmingham. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1081-1089DOI: (10.1016/S0022-5223(95)70191-5) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 9 Hazard function for a CAD event. It consists of a late phase only. The hazard function (instantaneous risk) is represented by the solid line and is surrounded by the 70% confidence limits (dashed lines). UAB, University of Alabama at Birmingham. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1081-1089DOI: (10.1016/S0022-5223(95)70191-5) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 10 Actuarial (Kaplan-Meier) freedom from a CAD event stratified by recipient gender. Circles, Female; squares, male. The error bars indicate 70% confidence limits. UAB, University of Alabama at Birmingham. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1081-1089DOI: (10.1016/S0022-5223(95)70191-5) Copyright © 1995 Mosby, Inc. Terms and Conditions