Treatment strategy. Treatment strategy. For every patient, changes of treatment were analysed per change, for up to five subsequent therapeutic changes.

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From: Treatment of Very Early Rheumatoid Arthritis With Symptomatic Therapy, Disease-Modifying Antirheumatic Drugs, or Biologic AgentsA Cost-Effectiveness.

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Presentation transcript:

Treatment strategy. Treatment strategy. For every patient, changes of treatment were analysed per change, for up to five subsequent therapeutic changes. Treatment changes are depicted numerically from 1 to 5. Med. 1 is equal to the first treatment initiated at disease onset. Med. 2 represents an alternative medication used at a subsequent visit, if Med. 1 was changed to another drug, independent of the reason for change. The total number of patients is shown who underwent a treatment change independent on the particular change (A), change of corticosteroid regimen (B), synthetic DMARD therapy (C), TNF antagonist treatment (D) and non-anti-TNF biological treatment (E). Therapeutic decisions for parts B–E of the figure are depicted as percentages of decisions taken in the different groups. All patients groups undergoing treatment changes are shown separately for non-radiographic (black) and radiographic (white) patients. ACR, American College of Rheumatology; DMARD, disease-modifying antirheumatic drug; EULAR, European League Against Rheumatism; TNF, tumour necrosis factor. Ruediger B Mueller et al. RMD Open 2018;4:e000673 Copyright © BMJ Publishing Group & EULAR. All rights reserved.