Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest Ru Lin,

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Presentation transcript:

Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest Ru Lin, MD, PhD, Ze-Wei Zhang, MD, Qi-Xing Xiong, MD, Chun-Mei Cao, PhD, Qiang Shu, MD, Iain C. Bruce, PhD, Qiang Xia, PhD The Annals of Thoracic Surgery Volume 78, Issue 3, Pages 970-975 (September 2004) DOI: 10.1016/j.athoracsur.2004.03.084

Fig 1 Recovery of intracellular calcium ([Ca2+]i) transient in isolated rat cardiomyocytes during perfusion with Krebs-Henseleit solution (95% O2/5% CO2 at 24°C) after cardioplegic arrest for 2 hours. Data are expressed as mean ± standard deviation. *p < 0.05; **p < 0.01 versus control (n = 8); ##p < 0.01 versus cardioplegic solution only (CP; n = 8); ΔΔp < 0.01 versus cardioplegic solution + pinacidil (CP+P; n = 12). (CP+P+G = cardioplegic solution + pinacidil + glibenclamide [n = 12].) The Annals of Thoracic Surgery 2004 78, 970-975DOI: (10.1016/j.athoracsur.2004.03.084)

Fig 2 Representative traces of calcium transients elicited by field stimulation and rapid application of caffeine. (CP = cardioplegic solution only; CP+P = cardioplegic solution + pinacidil; CP+P+G = cardioplegic solution + pinacidil + glibenclamide.) The Annals of Thoracic Surgery 2004 78, 970-975DOI: (10.1016/j.athoracsur.2004.03.084)

Fig 3 Box plot of the amplitude of the intracellular calcium ([Ca2+]i) transient evoked by the rapid application of caffeine (10 mmol/L). **p < 0.01 versus control (n = 8); ##p < 0.01 versus cardioplegic solution only (CP; n = 8); Δp < 0.05 versus cardioplegic solution + pinacidil (CP+P; n = 9). (CP = cardioplegic solution only; CP+P = cardioplegic solution + pinacidil; CP+P+G = cardioplegic solution + pinacidil + glibenclamide [n = 8].) The Annals of Thoracic Surgery 2004 78, 970-975DOI: (10.1016/j.athoracsur.2004.03.084)

Fig 4 Box plot of the ratio between the intracellular calcium ([Ca2+]i) transient's decay time in response to caffeine and that induced by electrical stimulation. *p < 0.05; **p < 0.01 versus control (n = 9); #p < 0.05; ##p < 0.01 versus cardioplegic solution only (CP; n = 8); ΔΔp < 0.01 versus cardioplegic solution + pinacidil (CP+P; n = 8). (CP = cardioplegic solution only; CP+P = cardioplegic solution + pinacidil; CP+P+G = cardioplegic solution + pinacidil + glibenclamide [n = 8].) The Annals of Thoracic Surgery 2004 78, 970-975DOI: (10.1016/j.athoracsur.2004.03.084)