Where is the lesion ?

Anisometropic Stimulus Deprivation Strabismic

Stimulus Deprivation Lid closure in cats or monkey, fine-detail cells (X cells) in the geniculate are larger than normal, and movement cells (Y cells) are smaller than normal (Sur M; 1982)

Stimulus Deprivation Projections from lateral geniculate nucleus to visual cortex are similarly affected. Cortical stripes from the affected eyes are narrower than normal (Hubel DH; 1975)

Anisometropic In primates given atropine, cells in visual cortex reduced contrast sensitivity; most prominent in striae cortex layer IV and IV (Movshon JA; 1987)

Strabismic Reduction of cells in the visual cortex (Kiorper L; 1981)

Strabismic amblyopic eye has thinner nerve fiber layer (Colen TP; 2000) Controversial (Baddini-Caramelli C; 2000)

Neurotransmitters ?? Anoxia increased central scotoma while oxygen had a beneficial effect ( Biette; 1950) GABA-receptor blocker (Bicuculline) in reversing visual deprivation (Duffy; 1955) Nerve growth factor prevented the shrinkage of cells in LGN(Maffei; 1993)

Role of levodopa and citicoline