Something we learn from textbook White fat cell Store energy Monolocular(单房的) Brown fat cell Dissipate energy [high mitochondrial UCP1(uncoupling protein 1)] Multilocular In small mammals, not in large mammals after infancy UCP1,tanslocating proton across mitochondrial membrane as to uncouple oxidation and phosphorylation, classically associated with the nonshivering thermogenesis of brown adipose tissue(BAT).

Some new progress “brown conversion”of white fat Brown fat in adult humans UCP1+ Particularly in supraclavicular and neck region cold or cAMP White fat tissue UCP1﹣ UCP1+ brown fat cell UCP1+ Derived from myf-5 lineage

Questions Beige fat cell is a distinct cell type or derived from white fat cells ？ The brown fat tissue in adult human is classical brown fat or beige fat ?

第一PPT模板网 Lecturer: Cao Lijie WAT: white adipose tissue BAT: brown adipose tissue Lecturer: Cao Lijie

Beige adipocyte in white fat Beige fat cell readily detectable in Inguinal subcutaneous fat depot Multilocular UCP1 between WAT and BAT BAT Inguinal subcutaneous fat depot Epididymal WAT Brown fat cell-enriched protein

Beige adipocyte in white fat Ing Immortalization(无限增殖) … … cell lines differentiate … … Inguinal subcutaneous fat depot Immortalizing(无限增殖) into 23 cell lines Gene expression analysis Two distinct adipose cell type, one of them is more similar to brown fat cell. A subset of clones precursor cells within white fat give rise to beige adipocyte beige fat cell White fat cell Beige fat cell is derived from a subset of precursor cells within white fat.

characteristics of Beige cells (By cAMP) reaching similar absolute level to that of BAT Brown fat-- enriched protein

Brown fat in adult humans are beige fat cells

highlights “Brown” fat in human adults is composed of beige adipocytes subQ WAT Beige adipogenic cells White adipogenic cells Sympathetic stimulation Beige adipocyte “Brown” fat in human adults is composed of beige adipocytes