Biology of Blood and Marrow Transplantation

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Presentation transcript:

Biology of Blood and Marrow Transplantation Effect of Graft-versus-Host Disease Prophylaxis Regimens on T and B Cell Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation Johan Törlén, Ahmed Gaballa, Mats Remberger, Lisa-Mari Mörk, Berit Sundberg, Jonas Mattsson, Michael Uhlin Biology of Blood and Marrow Transplantation DOI: 10.1016/j.bbmt.2019.01.029 Copyright © 2019 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Kinetics of excision circles at different time points after HSCT. (A) Median TREC levels with whiskers for upper/lower quartiles, according to treatment arm. (B) Median KREC levels with whiskers for upper/lower quartiles, according to treatment arm. (C) Median telomere levels with whiskers for upper/lower quartiles, according to treatment arm. Datasets are interleaved at each time point to improve readability. T, telomere amplification product; S, single-copy gene (β-globulin). Biology of Blood and Marrow Transplantation DOI: (10.1016/j.bbmt.2019.01.029) Copyright © 2019 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Impacts of transplantation factors on TREC levels after HSCT. (A) Impact of patient age. (B) Impact of ATG treatment. (C) Impact of graft source. Datasets are interleaved at each time point to improve readability. BM, bone marrow. Biology of Blood and Marrow Transplantation DOI: (10.1016/j.bbmt.2019.01.029) Copyright © 2019 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Impact of aGVHD on KREC kinetics at different time points after HSCT. Datasets are interleaved at each time point to improve readability. Biology of Blood and Marrow Transplantation DOI: (10.1016/j.bbmt.2019.01.029) Copyright © 2019 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Kinetics of telomeres at different time points after HSCT (all patients). Biology of Blood and Marrow Transplantation DOI: (10.1016/j.bbmt.2019.01.029) Copyright © 2019 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 Impact of median excision circle levels on transplantation outcomes. (A) TREC levels above/below median, TRM. (B) KREC levels above/below median, TRM. (C) TREC levels above/below median, OS. (D) KREC levels above/below median, OS. Biology of Blood and Marrow Transplantation DOI: (10.1016/j.bbmt.2019.01.029) Copyright © 2019 American Society for Blood and Marrow Transplantation Terms and Conditions