K. -C. Wang, E. Kwan, K. Aris, T. T. Egelhoff, A. I. Caplan, J. F

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The effect of RhoA/ROCK signaling inhibition on the development of hMSC-based chondrogenic tissue K.-C. Wang, E. Kwan, K. Aris, T.T. Egelhoff, A.I. Caplan, J.F. Welter, H. Baskaran Osteoarthritis and Cartilage Volume 25, Pages S77-S78 (April 2017) DOI: 10.1016/j.joca.2017.02.768 Copyright © 2017 Terms and Conditions

Figure 1 hMSC aggregates of control (left), Y27632 treatment for day 0–14 (middle) and day 0–21 (right) harvested after 21-day culture (top row) and stained with Safranin O (bottom row). Scale bars: 1 mm. Osteoarthritis and Cartilage 2017 25, S77-S78DOI: (10.1016/j.joca.2017.02.768) Copyright © 2017 Terms and Conditions

Figure 2 RhOA/ROCK inhibition increased GAG (2A Left) and collagen (2A Right) content in aggregates. The inhibition also increased glucose consumption rate (red line, 2B Left) and the amount of fluorescent tracer (10 kDa) transported into the aggregate over one hour (2B Right) (Number of aggregates ≥ 6 for all experiments). Osteoarthritis and Cartilage 2017 25, S77-S78DOI: (10.1016/j.joca.2017.02.768) Copyright © 2017 Terms and Conditions