The effect of mannitol versus dimethyl thiourea at attenuating ischemia/reperfusion- induced injury to skeletal muscle Michael George Schlag, PhD, Sharon.

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Presentation transcript:

The effect of mannitol versus dimethyl thiourea at attenuating ischemia/reperfusion- induced injury to skeletal muscle Michael George Schlag, PhD, Sharon Clarke, BSc, Michael W. Carson, MSc, Kenneth A. Harris, MD, FRCSC, Richard F. Potter, PhD Journal of Vascular Surgery Volume 29, Issue 3, Pages 511-521 (March 1999) DOI: 10.1016/S0741-5214(99)70280-6 Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Capillary perfusion. □, Control; ■, mannitol; ○, dimethyl thiourea; ●, sham; Pre-I, preischemic values; *, significantly different versus presichemic; †, significantly different versus control; ‡, significantly different versus preceeding timepoint. Journal of Vascular Surgery 1999 29, 511-521DOI: (10.1016/S0741-5214(99)70280-6) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 2 Tissue injury (ethidium bromide/bisbenzimide ratio). □, Control; ■, mannitol; ○, dimethyl thiourea; ●, sham; *, significantly different versus all other groups. Dimethyl thiourea significantly different from control and mannitol. Journal of Vascular Surgery 1999 29, 511-521DOI: (10.1016/S0741-5214(99)70280-6) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 3 Rolling leukocytes. □, Control; ■, mannitol; ○, dimethyl thiourea; Pre-I, preischemic values; *, significantly different versus preischemic; †, significantly different versus control; ‡, significantly different versus mannitol. Journal of Vascular Surgery 1999 29, 511-521DOI: (10.1016/S0741-5214(99)70280-6) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Adherent leukocytes. □, Control; ■, mannitol; ●, dimethyl thiourea; Pre-I, preischemic values; *, significantly different versus preischemic; †, significantly different versus control; ‡, significantly different versus mannitol. Journal of Vascular Surgery 1999 29, 511-521DOI: (10.1016/S0741-5214(99)70280-6) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Extravasated leukocytes. □, Control; ■, mannitol; ○, dimethyl thiourea; Pre-I, preischemic values; *, significantly different versus preischemic. Reperfusion values of dimethyl thiourea significantly different (analysis of variance) versus control and mannitol. Journal of Vascular Surgery 1999 29, 511-521DOI: (10.1016/S0741-5214(99)70280-6) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions