It takes two to Twist Kidney International

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Presentation transcript:

It takes two to Twist Kidney International Arjan J. Groot, Paul J. van Diest, Marc A. Vooijs Kidney International Volume 76, Issue 4, Pages 460-461 (August 2009) DOI: 10.1038/ki.2009.164 Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 1 Schematic representation of the TWIST1 genomic structure and the putative hypoxia-responsive elements (HREs) involved in TWIST1 regulation by hypoxia-inducible factor (HIF) proteins. Exons (white boxes), the coding sequence (gray box), and the HREs (black boxes) are shown here. Nucleotide positions of functional HREs in the TWIST1 genomic locus bound by HIF-1α or HIF-2α proteins in different systems are indicated (see text for details). EMT, epithelial–mesenchymal transition. Kidney International 2009 76, 460-461DOI: (10.1038/ki.2009.164) Copyright © 2009 International Society of Nephrology Terms and Conditions