Extent of Lymphadenectomy Is Associated With Improved Overall Survival After Esophagectomy With or Without Induction Therapy Pamela Samson, MD, MPHS,

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Presentation transcript:

Extent of Lymphadenectomy Is Associated With Improved Overall Survival After Esophagectomy With or Without Induction Therapy Pamela Samson, MD, MPHS, Varun Puri, MD, MSci, Stephen Broderick, MD, G. Alexander Patterson, MD, Bryan Meyers, MD, MPH, Traves Crabtree, MD The Annals of Thoracic Surgery Volume 103, Issue 2, Pages 406-415 (February 2017) DOI: 10.1016/j.athoracsur.2016.08.010 Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 (A) Although no difference in overall survival (OS) was detected in patients who had ≥15 lymph nodes examined when undergoing upfront esophagectomy, a significant difference was seen for (B) patients who received induction therapy at this threshold. (LN = lymph node; NCCN = National Comprehensive Cancer Network.) The Annals of Thoracic Surgery 2017 103, 406-415DOI: (10.1016/j.athoracsur.2016.08.010) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Kaplan-Meier curve comparing patients undergoing upfront esophagectomy who had less than or greater than 25 lymph nodes sampled demonstrates a significant difference in survival. (LN = lymph node.) The Annals of Thoracic Surgery 2017 103, 406-415DOI: (10.1016/j.athoracsur.2016.08.010) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Kaplan-Meier curves by positive to examined node (PEN) ratio for (A) patients undergoing upfront esophagectomy and (B) patients receiving induction therapy. The Annals of Thoracic Surgery 2017 103, 406-415DOI: (10.1016/j.athoracsur.2016.08.010) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Kaplan-Meier curve for patients undergoing esophagectomy with a positive to examined node (PEN) ratio of 0 by examined lymph node number. (LN = lymph node.) The Annals of Thoracic Surgery 2017 103, 406-415DOI: (10.1016/j.athoracsur.2016.08.010) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions