High-power view of high-grade dysplasia with intramucosal adenocarcinoma. High-power view of high-grade dysplasia with intramucosal adenocarcinoma. The intramucosal adenocarcinoma is characterised by a proliferation of small irregular glands with markedly atypical nuclei infiltrating the lamina propria in a haphazard fashion that cannot be explained on the basis of involvement of pre-existing crypts. R D Odze J Clin Pathol 2006;59:1029-1038 Copyright © by the BMJ Publishing Group Ltd & Association of Clinical Pathologists. All rights reserved.