Crosslinking Mass Spectrometry Goes In-Tissue

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Crosslinking Mass Spectrometry Goes In-Tissue Andrea Sinz Cell Systems Volume 6, Issue 1, Pages 10-12 (January 2018) DOI: 10.1016/j.cels.2018.01.005 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Crosslinking/MS Advances from an In Vitro to an In Vivo Approach Exemplary literature references are provided for MS-cleavable crosslinkers. These linkers, together with improved MS and bioinformatics tools, enable the analysis of protein conformations and protein-protein interactions of increasingly complex samples, including whole cells, functional organelles, and tissues. SuDP, disuccinimidyl-succinamyl-aspartyl-proline; DSBU, disuccinimidyl dibutyric urea; DSSO, disuccinimidyl sulfoxide. Figure credit: Christian Arlt. Cell Systems 2018 6, 10-12DOI: (10.1016/j.cels.2018.01.005) Copyright © 2018 Elsevier Inc. Terms and Conditions