Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study Y.S. Kim,

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Presentation transcript:

Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study Y.S. Kim, Y.J. Choi, S.W. Lee, O.R. Kwon, D.S. Suh, D.B. Heo, Y.G. Koh Osteoarthritis and Cartilage Volume 24, Issue 2, Pages 237-245 (February 2016) DOI: 10.1016/j.joca.2015.08.009 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 (A) An articular cartilage lesion in the medial femoral condyle was noticed during arthroscopy. (B) Arthroscopic implantation of MSCs loaded in fibrin glue. The cartilage lesion was covered with the cell thrombin–fibrinogen suspension after manipulation with the probe. Osteoarthritis and Cartilage 2016 24, 237-245DOI: (10.1016/j.joca.2015.08.009) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 (A and B) Preoperative fat-saturated proton density coronal and sagittal images of the right knee of a 58-year-old female patient. Cartilage loss (grade 2 for size of cartilage loss as a percentage of surface area and grade 3 for percentage of full-thickness cartilage loss of the region according to the MOAKS) was observed in the medial femoral condyle (arrows). (C and D) Follow-up fat-saturated proton density coronal and sagittal images. Complete filling of the defect along with complete integration with the adjacent native cartilage (grade 0 for size of cartilage loss as a percentage of surface area and grade 0 for percentage of full-thickness cartilage loss of the region according to MOAKS) with 75 points of MOCART score was observed (arrows). Osteoarthritis and Cartilage 2016 24, 237-245DOI: (10.1016/j.joca.2015.08.009) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 (A and B) Preoperative fat-saturated proton density coronal and sagittal images of the right knee of a 60-year-old male patient. Cartilage loss (grade 2 for size of cartilage loss as a percentage of surface area and grade 3 for percentage of full-thickness cartilage loss of the region according to the MOAKS) was observed in the medial femoral condyle (arrows). (C and D) Follow-up fat-saturated proton density coronal and sagittal images. Incomplete filling of the defect along with incomplete integration with the adjacent native cartilage (grade 1 for size of cartilage loss as a percentage of surface area and grade 2 for percentage of full-thickness cartilage loss of the region according to MOAKS) with 60 points of MOCART score was observed (arrows). Osteoarthritis and Cartilage 2016 24, 237-245DOI: (10.1016/j.joca.2015.08.009) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions