Looking into the Black Box: New Directions in Neuroimaging

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Looking into the Black Box: New Directions in Neuroimaging Stephen A. Engel  Neuron  Volume 17, Issue 3, Pages 375-378 (September 1996) DOI: 10.1016/S0896-6273(00)80170-1

Figure 1 Stimuli Used to Map Retinotopic Organization in Cortex Stimuli are composed of a contrast-reversing checkerboard pattern flickering at a high temporal rate (e.g., 8 Hz). (A) A rotating stimulus is shown at five moments in time spanning one stimulus cycle; a typical cycle length is 45 s. (B) At each location within the visual field, the stimulus alternates with the uniform gray field. Visual field locations further along the direction of rotation receive stimulation later in time. Hence, this stimulus encodes polar angle (Θ in a polar coordinate system) as temporal delay. Two stimulus cycles are shown. (C) An expanding stimulus is shown at five moments in time spanning one stimulus cycle. This stimulus encodes eccentricity (distance from the fixation point; r in a polar coordinate system) as temporal delay. Neuron 1996 17, 375-378DOI: (10.1016/S0896-6273(00)80170-1)

Figure 2 Borders of Early Visual Areas Identified Using Retinotopic Organization Measured with fMRI Retinotopy with respect to polar angle was measured as delay in the fMRI signal using the rotating stimulus. The data are represented on a computationally flattened medial occipital lobe; up is superior, down is inferior. In humans, V1 is located in the calcarine sulcus, which runs in the medial wall of the occipital lobe; the dashed line traces the deepest part of the calcarine sulcus, and the star indicates the position of the occipital pole. Color represents measured polar angle. Reversals in the change of the polar angle representation can be identified at positions above and below the calcarine sulcus. These are evident as a gradual change toward one color (e.g., from red to green moving dorsally) adjacent to a change in the opposite direction (e.g. from green to red). The reversals near the calcarine identify the boundaries between area V1 and V2. Other reversals identify the V2/V3 boundary and the V2/VP boundary. Data are taken from Engel et al., 1996. Neuron 1996 17, 375-378DOI: (10.1016/S0896-6273(00)80170-1)