Risk-adapted survival benefit of IMRT in early-stage NKTCL: a multicenter study from the China Lymphoma Collaborative Group by Tao Wu, Yong Yang, Su-Yu.

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Risk-adapted survival benefit of IMRT in early-stage NKTCL: a multicenter study from the China Lymphoma Collaborative Group by Tao Wu, Yong Yang, Su-Yu Zhu, Mei Shi, Hang Su, Ying Wang, Xia He, Li-Ming Xu, Zhi-Yong Yuan, Li-Ling Zhang, Gang Wu, Bao-Lin Qu, Li-Ting Qian, Xiao-Rong Hou, Fu-Quan Zhang, Yu-Jing Zhang, Yuan Zhu, Jian-Zhong Cao, Sheng-Min Lan, Jun-Xin Wu, Chen Hu, Shu-Nan Qi, Bo Chen, and Ye-Xiong Li BloodAdv Volume 2(18):2369-2377 September 25, 2018 © 2018 by The American Society of Hematology

Tao Wu et al. Blood Adv 2018;2:2369-2377 © 2018 by The American Society of Hematology

Treatment trends in RT techniques and doses for evaluable patients with early-stage NKTCL. Proportion of patients receiving IMRT vs 3D-CRT (A) and RT doses ≥ 50 Gy vs <50 Gy (B) between 2000 and 2015. Treatment trends in RT techniques and doses for evaluable patients with early-stage NKTCL. Proportion of patients receiving IMRT vs 3D-CRT (A) and RT doses ≥ 50 Gy vs <50 Gy (B) between 2000 and 2015. Tao Wu et al. Blood Adv 2018;2:2369-2377 © 2018 by The American Society of Hematology

Survival benefit of IMRT over 3D-CRT in early-stage NKTCL Survival benefit of IMRT over 3D-CRT in early-stage NKTCL. OS and PFS after IMRT or 3D-CRT for the entire cohort (A-B) and for the PSM cohort (C-D). Survival benefit of IMRT over 3D-CRT in early-stage NKTCL. OS and PFS after IMRT or 3D-CRT for the entire cohort (A-B) and for the PSM cohort (C-D). Tao Wu et al. Blood Adv 2018;2:2369-2377 © 2018 by The American Society of Hematology

Forest plots representing OS and PFS after IMRT or 3D-CRT for different subgroups. Forest plots representing OS and PFS after IMRT or 3D-CRT for different subgroups. HRs are derived from multivariate Cox proportional hazards models, with 95% CIs and P values for OS and PFS. The area of the squares is proportional to sample size. The vertical dashed line is the HR for comparison in the entire cohort. Tao Wu et al. Blood Adv 2018;2:2369-2377 © 2018 by The American Society of Hematology

Improved survival for IMRT vs 3D-CRT after new-regimen chemotherapy. Improved survival for IMRT vs 3D-CRT after new-regimen chemotherapy. OS (A) and PFS (B) for IMRT or 3D-CRT in patients with early-stage NKTCL receiving asparaginase- or gemcitabine-based chemotherapy. Tao Wu et al. Blood Adv 2018;2:2369-2377 © 2018 by The American Society of Hematology

Varied survival benefit profile of IMRT vs 3D-CRT based on NKTCL-PI. Varied survival benefit profile of IMRT vs 3D-CRT based on NKTCL-PI. Patients with early-stage NKTCL were stratified into 4 risk groups with different OS (A) and PFS (B). HRs for OS (C) and PFS (D) for IMRT vs 3D-CRT within different risk subgroups defined by NKTCL-PI. Forest plots showing improved OS (C) and PFS (D) for IMRT compared with 3D-CRT in patients at intermediate-high or high risk but limited benefit of IMRT in patients at low or intermediate-low risk. Tao Wu et al. Blood Adv 2018;2:2369-2377 © 2018 by The American Society of Hematology