Volume 135, Issue 4, Pages (October 2008)

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Volume 135, Issue 4, Pages 1192-1199 (October 2008) HBsAg Seroclearance in Chronic Hepatitis B in Asian Patients: Replicative Level and Risk of Hepatocellular Carcinoma  Man–Fung Yuen, Danny Ka–Ho Wong, James Fung, Philip Ip, David But, Ivan Hung, Kevin Lau, John Chi–Hang Yuen, Ching–Lung Lai  Gastroenterology  Volume 135, Issue 4, Pages 1192-1199 (October 2008) DOI: 10.1053/j.gastro.2008.07.008 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Analysis of the expression of HBV X mRNA and the β-actin mRNA in the liver tissues. Expressions of precore/pregenomic and S mRNA were not detectable in the liver tissues of all 11 patients (lanes 1–11) and hence not shown. Top panel: expression of X mRNA. Bottom panel: expression of β-actin mRNA. M, 50-bp DNA molecular markers; lanes 1–11: patients 1–11; “−”, negative controls, with HBV DNA cloned in a plasmid and digested with RNase-free DNase; “+”, positive controls, with mRNA extracted from a chronic hepatitis B patient. Gastroenterology 2008 135, 1192-1199DOI: (10.1053/j.gastro.2008.07.008) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Cumulative risk for the development of HCC in patients with HBsAg seroclearance at age <50 and ≥50 years. Gastroenterology 2008 135, 1192-1199DOI: (10.1053/j.gastro.2008.07.008) Copyright © 2008 AGA Institute Terms and Conditions