Blood Vessel Formation: What Is Its Molecular Basis?

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Blood Vessel Formation: What Is Its Molecular Basis? Judah Folkman, Patricia A. D'Amore Cell Volume 87, Issue 7, Pages 1153-1155 (December 1996) DOI: 10.1016/S0092-8674(00)81810-3 Copyright © 1996 Cell Press Terms and Conditions

Figure 1 Venous Malformations Top: Child with a venous malformation. Bottom: Diagrams to show the histological difference between normal veins and a venous malformation. With increasing luminal diameter, normal veins are lined by increasing numbers of endothelial cells in a monolayer, and increasing numbers of smooth muscle cells in multiple layers. In contrast, as the luminal diameter of venous malformations increases, the number of smooth muscle layers does not increase. Cell 1996 87, 1153-1155DOI: (10.1016/S0092-8674(00)81810-3) Copyright © 1996 Cell Press Terms and Conditions

Figure 1 Venous Malformations Top: Child with a venous malformation. Bottom: Diagrams to show the histological difference between normal veins and a venous malformation. With increasing luminal diameter, normal veins are lined by increasing numbers of endothelial cells in a monolayer, and increasing numbers of smooth muscle cells in multiple layers. In contrast, as the luminal diameter of venous malformations increases, the number of smooth muscle layers does not increase. Cell 1996 87, 1153-1155DOI: (10.1016/S0092-8674(00)81810-3) Copyright © 1996 Cell Press Terms and Conditions

Figure 2 A Proposed Model for the Recruitment of Mesenchmal Cells to Developing Vessels Angiopoietin-1 released by mesenchymal cells binds TIE2 receptor and activates (or releases) a signal from the endothelial cell that recruits local mesenchymal cells to the forming vessel. Upon contact with the endothelium, TGFβ is activated from its latent state, causing mesenchymal cells to differentiate into pericytes and smooth muscle cells, inhibition of endothelial proliferation (Antonelli-Orlidge et al. 1989), and accumulation of extracellular matrix. Cell 1996 87, 1153-1155DOI: (10.1016/S0092-8674(00)81810-3) Copyright © 1996 Cell Press Terms and Conditions