Predicting Iron Overload in Hyperferritinemia John K. Olynyk, Eng Gan, Terrence Tan  Clinical Gastroenterology and Hepatology  Volume 7, Issue 3, Pages 359-362 (March 2009) DOI: 10.1016/j.cgh.2008.11.010 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 HIC in the 3 hyperferritinemic study groups. Group 1 subjects had increased TRS and serum ferritin levels and no significant HFE mutations; group 2 had increased TRS and serum ferritin levels and C282Y homozygosity or C282Y/H63D compound heterozygosity; group 3 had increased serum ferritin levels only. Group 2 subjects had significantly higher HIC compared with the other 2 groups (P < .01). None of the subjects in groups 1 and 3 had increases of the HIC to greater than 3 × ULN compared with 9 of 22 subjects in group 2 (P < .01). *P < .05 versus groups 1 and 3 (chi-square test). **P < .01 versus groups 1 and 3 (chi-square test). ***P < .01 versus groups 1 and 3 (unpaired t test). Clinical Gastroenterology and Hepatology 2009 7, 359-362DOI: (10.1016/j.cgh.2008.11.010) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 Correlation between serum ferritin levels and HIC in the 3 study groups. Ferritin levels were correlated positively with HIC in group 2 subjects with HFE HH. No relationship was observed between serum ferritin levels and HIC in the other 2 groups. (A) Group 1; (B) group 2; and (C) group 3. Clinical Gastroenterology and Hepatology 2009 7, 359-362DOI: (10.1016/j.cgh.2008.11.010) Copyright © 2009 AGA Institute Terms and Conditions