Volume 57, Issue 5, Pages (May 2000)

Slides:

Advertisements

Similar presentations

Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure William C. Wolf, Hideaki.

Advertisements

Volume 62, Issue 5, Pages (November 2002)

Volume 73, Issue 11, Pages (June 2008)

Volume 56, Issue 3, Pages (September 1999)

Gene expression of prostanoid forming enzymes along the rat nephron1

Volume 60, Issue 4, Pages (October 2001)

Volume 64, Issue 1, Pages (July 2003)

Volume 63, Issue 3, Pages (March 2003)

Volume 64, Issue 3, Pages (September 2003)

Boye L. Jensen, Bianca Mann, Ole Skøtt, Armin Kurtz

Li Cui, Raymond K. Blanchard, Robert J. Cousins Kidney International

The prolactin gene is expressed in the mouse kidney

Volume 56, Issue 6, Pages (December 1999)

Volume 62, Issue 4, Pages (October 2002)

Expression of somatostatin in the adult and developing mouse kidney

Volume 61, Issue 5, Pages (May 2002)

Volume 55, Issue 5, Pages (May 1999)

Volume 65, Issue 4, Pages (April 2004)

Adenovirus-mediated kallikrein gene delivery reverses salt-induced renal injury in Dahl salt-sensitive rats Julie Chao, Jenny J. Zhang, Kuei-Fu Lin,

Hiroshi Murakami, Lance Liotta, Robert A. Star Kidney International

Rat mesangial α-endosulfine

Nephron specific regulation of chloride channel CLC-K2 mRNA in the rat

Interstitial tonicity controls TonEBP expression in the renal medulla

Volume 61, Issue 6, Pages (June 2002)

Differential expression of adenylyl cyclases in the rat nephron

Volume 62, Issue 5, Pages (November 2002)

Volume 65, Issue 6, Pages (June 2004)

Volume 54, Issue 3, Pages (September 1998)

IL-18 is expressed in the intercalated cell of human kidney

Volume 60, Issue 5, Pages (November 2001)

Volume 59, Issue 4, Pages (April 2001)

Down-regulation of Na+ transporters and AQP2 is responsible for acyclovir-induced polyuria and hypophosphatemia Lúcia Andrade, Nancy A. Rebouças, Antonio.

Volume 67, Issue 5, Pages (May 2005)

Yukimasa Kohda, Hiroshi Murakami, Orson W. Moe, Robert A. Star

Magnus Åbrink, Eric Larsson, Anders Gobl, Lars Hellman

Volume 54, Pages S136-S138 (September 1998)

Volume 65, Issue 6, Pages (June 2004)

Volume 57, Issue 4, Pages (April 2000)

Volume 61, Issue 6, Pages (June 2002)

Kenji Kasuno, Hajime Nakamura, Takahiko Ono, Eri Muso, Junji Yodoi

17-β Estradiol attenuates streptozotocin-induced diabetes and regulates the expression of renal sodium transporters S. Riazi, C. Maric, C.A. Ecelbarger

Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure William C. Wolf, Hideaki.

Volume 67, Issue 1, Pages (January 2005)

Glucocorticoids enhance the expression of the basolateral Na+:HCO3- cotransporter in renal proximal tubules Raza Ali, Hassane Amlal, Charles E. Burnham,

Volume 63, Issue 2, Pages (February 2003)

Volume 58, Issue 2, Pages (August 2000)

Volume 59, Issue 1, Pages (January 2001)

Volume 64, Issue 2, Pages (August 2003)

Volume 69, Issue 2, Pages (January 2006)

Distribution of postsynaptic density proteins in rat kidney: Relationship to neuronal nitric oxide synthase Akihiro Tojo, David S. Bredt, Christopher.

Resistance of mTAL Na+-dependent transporters and collecting duct aquaporins to dehydration in 7-month-old rats Hassane Amlal, Catherine Wilke Kidney.

Nitric oxide, enhanced by macrophage-colony stimulating factor, mediates renal damage in reflux nephropathy Udo Rolle, Hideki Shima, Prem Puri Kidney.

Increased endothelin-1 expression in the kidney in hypercalcemic rats

Babu J. Padanilam, Andrew J.P. Lewington, Marc R. Hammerman

Insulin resistance and hypertension: new insights

Zinc deficiency further increases the enhanced expression of endothelin-1 in glomeruli of the obstructed kidney Hiroyuki Yanagisawa, Kazuaki Moridaira,

H. Raffi, J.M. Bates, Z. Laszik, S. Kumar Kidney International

Endothelin antagonists in renal disease

Volume 53, Issue 5, Pages (May 1998)

Increased renal calcium and magnesium transporter abundance in streptozotocin- induced diabetes mellitus C-T. Lee, Y-H.H. Lien, L-W. Lai, J-B. Chen, C-R.

Volume 58, Issue 6, Pages (December 2000)

Volume 63, Issue 6, Pages (June 2003)

Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia S. Faroqui, M. Levi,

Volume 61, Issue 1, Pages (January 2002)

Cl- channels in basolateral TAL membranes. XVI

Volume 65, Issue 6, Pages (June 2004)

Volume 60, Issue 2, Pages (August 2001)

Volume 65, Issue 6, Pages (June 2004)

Volume 59, Issue 1, Pages (January 2001)

Volume 66, Issue 1, Pages (July 2004)

Presentation transcript:

Volume 57, Issue 5, Pages 2055-2063 (May 2000) Cardiac infarcts increase sodium transporter transcripts (rBSC1) in the thick ascending limb of Henle Shoji Nogae, Mari Michimata, Masayuki Kanazawa, Satoko Honda, Masahiro Ohta, Yutaka Imai, Sadayoshi Ito, Mitsunobu Matsubara Kidney International Volume 57, Issue 5, Pages 2055-2063 (May 2000) DOI: 10.1046/j.1523-1755.2000.00054.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Histological sections of the heart through the midwall of the left ventricle. (A) Infarct size of 15%. (B) Infarct size of 30%. Trichrome stain. Kidney International 2000 57, 2055-2063DOI: (10.1046/j.1523-1755.2000.00054.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 (A) Competitive polymerase chain reaction (PCR) or rat bumetamide-sensitive sodium cotransporter (rBSC1) transcripts using total RNAs from the renal outer medulla. (B) The signal intensities of mimic cDNA (▴) and intrinsic rBSC1 (○) are plotted against the amount of mimic cDNA. The amount of rBSC1 mRNA in the sample was calculated from the equivalent point (mimic cDNA/intrinsic rBSC1 = 1.0). (C) Mean data of eight such determinations in the outer medulla and cortex (±SD). *P < 0.01 compared with sham-operated rats. Abbreviations are: S, sham-operated; MI, myocardial infarction. Kidney International 2000 57, 2055-2063DOI: (10.1046/j.1523-1755.2000.00054.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Changes in rBSC1 expression. (A) In situ hybridization of the inner stripe of the outer medulla. (B) Immunohistochemistry of the inner stripe of outer medulla. (Magnification, ×200). Kidney International 2000 57, 2055-2063DOI: (10.1046/j.1523-1755.2000.00054.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Immunoblots of rBSC1. Total protein (150 μg) from renal outer medulla was loaded in each lane. A mature band appears approximately 130 kDa, which is enhanced in myocardial infarcted rats. Kidney International 2000 57, 2055-2063DOI: (10.1046/j.1523-1755.2000.00054.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 5 (A) Competitive PCR of AQP2 transcripts using total RNAs from the renal outer medulla. (B) The signal intensities of mimic cDNA (▴) and intrinsic AQP2 (○) are plotted against the amount of mimic cDNA. The amount of AQP2 mRNA in the sample was calculated from the equivalent point (mimic cDNA/intrinsic AQP2 = 1.0). (C) The mean data of eight such determinations (±SD) of the inner medulla, outer medulla, and cortex. Abbreviations are: S, sham-operated; M, myocardial infarcted; D, dehydrated as a positive control. *P < 0.01 compared with sham-operated rats. Kidney International 2000 57, 2055-2063DOI: (10.1046/j.1523-1755.2000.00054.x) Copyright © 2000 International Society of Nephrology Terms and Conditions