S:ShamR:Real

Real Moxibustion Sham Moxibustion SBF Temp Pain SBF Temp Pain Max None 5 ml/min/100g Max None 1 min 5 ml/min/100g Max None

PRE

PRE

SBF Temp Pain ml/min/100g Max. None 1 min

Polymodal Receptor Hypothesis Polymodal Receptor Bio-regulatory Systems Endogenous pain inhibition, autonomic and endocrine systems Acupuncture (mechanical) Moxibustion (thermal,chemical) Responsive to mechanical, thermal and chemical stimuli Free nerve endings Flare & wheal (axon reflex) Sensitized polymodal receptor is candidate of the tender, trigger and acupuncture point Distributes to the skin, muscle and viscera of entire body

Fig.4 Effect of Moxibustion on Skin Temperature Data are shown as the mean and SD

Fig.5 Effect of Moxibustion on Blood Flow Real Moxibustion; Sham Moxibustion Skin Blood flow is shown as ml/min/100g Fig.6 Repetitive Application of Moxibustion on Skin Blood Flow and Pain Magnitude SBF:Skin blood flow; Temp: Skin temperature; Pain: Magnitude of Pain