CaFE Server Siteman Cancer Center. Introduction Annotate probes on microarrays using publicly available biomedical databases Automatically update annotations.

Slides:



Advertisements
Similar presentations
Introduction The cancerGrid metadata registry (cgMDR) has proved effective as a lightweight, desktop solution, interoperable with caDSR, targeted at the.
Advertisements

Overview of LexEVS 5.0 LexEVS Architecture November, 2009.
Kino : Making Semantic Annotations Easier Ajith Ranabahu #, Priti Parikh #, Maryam Panahiazar #, Amit Sheth # and Flora Logan- Klumpler* # Ohio Center.
11 caGrid adoption at the NCRI Informatics Initiative in the UK ONIX use of caGrid technology Edward Zukowski July, 2009.
ANSC644 Bioinformatics-Database Mining 1 ANSC644 Bioinformatics §Carl J. Schmidt §051 Townsend Hall §
Creating NCBI The late Senator Claude Pepper recognized the importance of computerized information processing methods for the conduct of biomedical research.
Introduction to BioConductor Friday 23th nov 2007 Ståle Nygård Statistical methods and bioinformatics for the analysis of microarray.
Genome databases and webtools for genome analysis Become familiar with microbial genome databases Use some of the tools useful for analyzing genome Visit.
Oncomine Database Lauren Smalls-Mantey Georgia Institute of Technology June 19, 2006 Note: This presentation contains animation.
Pathways analysis Iowa State Workshop 11 June 2009.
Provenance in a Collaborative Bio-database RAASWiki Donald Dunbar & Jon Manning Queen’s Medical Research Institute University of Edinburgh Use Cases for.
The National Center for Biotechnology Information (NCBI) a primary resource for molecular biology information Database Resources.
Prof. Carolina Ruiz Computer Science Department Bioinformatics and Computational Biology Program WPI WELCOME TO BCB4003/CS4803 BCB503/CS583 BIOLOGICAL.
The design, construction and use of software tools to generate, store, annotate, access and analyse data and information relating to Molecular Biology.
Five Slides About EGAN Jesse Paquette UCSF Helen Diller Family Comprehensive Cancer Center
1 CBioC: Collaborative Bio- Curation Chitta Baral Department of Computer Science and Engineering Arizona State University.
Kate Milova MolGen retreat March 24, Microarray experiments: Database and Analysis Tools. Kate Milova cDNA Microarray Facility March 24, 2005.
Overall Information Extraction vs. Annotating the Data Conference proceedings by O. Etzioni, Washington U, Seattle; S. Handschuh, Uni Krlsruhe.
Kate Milova MolGen retreat March 24, Microarray experiments. Database and Analysis Tools. Kate Milova cDNA Microarray Facility March 24, 2005.
IST Computational Biology1 Information Retrieval Biological Databases 2 Pedro Fernandes Instituto Gulbenkian de Ciência, Oeiras PT.
Kate Milova MolGen retreat March 24, Microarray experiments. Database and Analysis Tools. Kate Milova cDNA Microarray Facility March 24, 2005.
Introduction to Bioinformatics - Tutorial no. 12
Kate Milova MolGen retreat March 24, Microarray experiments. Database and Analysis Tools. Kate Milova cDNA Microarray Facility March 24, 2005.
B IOMEDICAL T EXT M INING AND ITS A PPLICATION IN C ANCER R ESEARCH Henry Ikediego
Doug Brutlag Professor Emeritus Biochemistry & Medicine (by courtesy) Genome Databases Computational Molecular Biology Biochem 218 – BioMedical Informatics.
Introductory Overview
1 ArrayExpress and MAGE Jamboree II Ugis Sarkans, EBI.
OpenMDR: Generating Semantically Annotated Grid Services Rakesh Dhaval Shannon Hastings.
OpenMDR: Alternative Methods for Generating Semantically Annotated Grid Services Rakesh Dhaval Shannon Hastings.
LexEVS Overview Mayo Clinic Rochester, Minnesota June 2009.
Cancer Nanotechnology Knowledgebase for Nanoparticle Analysis and Design caOBR-caB2B integration Nathan Baker, David Paik, and Persistent Systems.
Using the Open Metadata Registry (openMDR) to create Data Sharing Interfaces October 14 th, 2010 David Ervin & Rakesh Dhaval, Center for IT Innovations.
CaBench-to-Bedside (caB2B) A caGrid TM client to facilitate translational research Key Stakeholders Involved: Developer Washington University Persistent.
Intralab Workshop - Reactome CMAP Chang-Feng Quo June 29 th, 2006.
CANDID: A candidate gene identification tool Janna Hutz March 19, 2007.
Taverna Workflow. A suite of tools for bioinformatics Fully featured, extensible and scalable scientific workflow management system – Workbench, server,
Building and Running caGrid Workflows in Taverna 1 Computation Institute, University of Chicago and Argonne National Laboratory, Chicago, IL, USA 2 Mathematics.
H Using the Open Metadata Registry (OpenMDR) to generate semantically annotated grid services Rakesh Dhaval, MS, Calixto Melean,
Affymetrix/BioCarta comparison & Java-based pathway analysis Michael Edmonson 2/26/2003.
Phase II Additions to LSG Search capability to Gene Browser –Though GUI in Gene Browser BLAST plugin that invokes remote EBI BLAST service Working set.
Introduction to caArray caBIG ® Molecular Analysis Tools Knowledge Center April 3, 2011.
GeWorkbench Highlights caBIG ® Molecular Analysis Tools Knowledge Center AACR Annual Meeting, April 3, 2011.
McLean HIGHER COMPUTER NETWORKING Lesson 7 Search engines Description of search engine methods.
Alastair Kerr, Ph.D. WTCCB Bioinformatics Core An introduction to DNA and Protein Sequence Databases.
Biological databases Exercises. Discovery of distinct sequence databases using ensembl.
NCBI Literature Databases: PubMed
1 Cancer Models Database (caMOD). 2 History  January 2000 – Prototype is presented during the Mouse Models of Human Cancers (MMHCC) Steering Committee.
2009 IADR, MIAMI, FL, USA Hands-on Experience for using the Human Oral Microbiome Database (HOMD) 2009 IADR Workshop, Miami, FL, USA Tsute (George) Chen.
A collaborative tool for sequence annotation. Contact:
1 Service Creation, Advertisement and Discovery Including caCORE SDK and ISO21090 William Stephens Operations Manager caGrid Knowledge Center February.
WINDOWS AZURE MOBILE SERVICES AN INTRODUCTION Bret Stateham Technical Evangelist
SUPPLEMENTAL FIGURES AND TABLES. Supplementary Table 1: List of new and improved features in GSEA-P version 2 Java software. Examples and screenshots.
EBI is an Outstation of the European Molecular Biology Laboratory. Gautier Koscielny VectorBase Meeting 08 Feburary 2012, EBI VectorBase Text Search Engine.
Copyright OpenHelix. No use or reproduction without express written consent1.
GeWorkbench Overview Support Team Molecular Analysis Tools Knowledge Center Columbia University and The Broad Institute of MIT and Harvard.
Design for a High Performance, Configurable caGrid Data Services Platform Peter Hussey LabKey Software, Inc, Seattle, WA USA Contact:
Copyright OpenHelix. No use or reproduction without express written consent1 1.
University of Illinois at Urbana-Champaign. BeeSpace Project 5-year NSF-funded project Project Goals  Develop open bioinformatics resources  Support.
Exercise 1 Database searches. Tasks of the day Learn to use NCBI ENTREZ (gquery) GQuery: NCBI Global Cross-database Search PubMed PMC Taxonomy PopSet.
CaGrid Workflow Examples Wei Tan, Ravi Madduri University of Chicago {wtan,
NCBI PubMed NCBI Literature Databases: PubMed Session #1, April 28, 2005 Session #2, April 29, 2005 Ho Chi Minh City, VietNam.
EBI is an Outstation of the European Molecular Biology Laboratory. Semantic Interoperability Framework Sarala M. Wimalaratne (RICORDO project)
GeneConnect Use Cases and Design August 3, GeneConnect Database IDs are linked by Direct Annotation, Inferred Annotation, or Sequence Alignment.
GEO (Gene Expression Omnibus) Deepak Sambhara Georgia Institute of Technology 21 June, 2006.
ARCH/VCDE F2F BoF And the Presentation Subtitle Goes Here Ravi Madduri December 2008.
Bio-Medical Text Mining with Python Jaganadh G Carlos Rodriguez-Penagos.
Annotation: linking literature to gene products
NCBI What is NCBI? PubMed OMIM Blast Entrez and more.
Biological Databases BI420 – Introduction to Bioinformatics
Gene Safari (Biological Databases)
Presentation transcript:

caFE Server Siteman Cancer Center

Introduction Annotate probes on microarrays using publicly available biomedical databases Automatically update annotations on a regular basis Web-based and API based query search Uses caCORE SDK (version 1.0.3) generated code Working towards caGRID compliance

Data Sources Entrez Gene UniGene Gene Ontology dbSNP UniSTS HomoloGene PubMed

Annotation Interlinks Microarrays CustomcaArray Entrez GeneUniGeneGenBank Accession NumberUniGene ClusterIDGene ID HomoloGenedbSNPPubMedGene Ontology Orthologus genesRefSNP IDPubmed relationship GO terms

Limitations Initial run of PubMed data curation takes 2-3 months APIs generated using caCORE SDK Not optimized for complex searches Performing searches that involves complex computations. For example, searching for literature correlation with depth 2 or more Meta-information of caArray is not stored

Demo