Novel CALM3 mutations in pediatric long QT syndrome patients support a CALM3- specific calmodulinopathy Marie-A. Chaix, MD, MSc, Tamara T. Koopmann, PhD,

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Presentation transcript:

Novel CALM3 mutations in pediatric long QT syndrome patients support a CALM3- specific calmodulinopathy Marie-A. Chaix, MD, MSc, Tamara T. Koopmann, PhD, Philippe Goyette, PhD, Azadeh Alikashani, MSc, Frédéric Latour, MSc, Meena Fatah, HBSc, Robert M. Hamilton, MD, John D. Rioux, PhD HeartRhythm Case Reports Volume 2, Issue 3, Pages 250-254 (May 2016) DOI: 10.1016/j.hrcr.2016.02.002 Copyright © 2016 Heart Rhythm Society Terms and Conditions

Figure 1 Electrocardiogram (ECG) recordings of subjects 1 and 2. ECGs of subject 1 A: recorded at birth, showing an extreme QTc interval (623 ms) and a 2:1 atrioventricular block (P waves indicated by black arrows), B: at 1 day of age, showing a sinus bradycardia (heart rate of 92 beats per minute [bpm]) and an extreme QTc interval prolongation (645 ms), and C: at 12 years, showing an extreme QTc interval prolongation (566 ms) and an atrial paced rhythm. ECGs of subject 2 recorded D: at 3 days of age, showing a sinus bradycardia (heart rate at 83 bpm) and an extreme QTc interval prolongation (627 ms); and E: at 15 years, showing ventricular paced rhythm at 90 bpm alternating with sinus conducted beats and a QTc interval that remains long (480 ms). HeartRhythm Case Reports 2016 2, 250-254DOI: (10.1016/j.hrcr.2016.02.002) Copyright © 2016 Heart Rhythm Society Terms and Conditions

Figure 2 Schematic model of calmodulin and long QT syndrome (LQTS) mutations. Schematic presentation of the calmodulin amino acid sequence showing the N-terminal and C-terminal domains, each containing 2 Ca2+ binding motifs (in orange). The locations of all published CALM1 (red), CALM2 (purple) and CALM3 (*,**,~) LQTS mutations are shown. The CALM3 mutations p.Asp96His and p.Phe142Leu were identified in this study. HeartRhythm Case Reports 2016 2, 250-254DOI: (10.1016/j.hrcr.2016.02.002) Copyright © 2016 Heart Rhythm Society Terms and Conditions