Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ischemic preconditioning during.

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Presentation transcript:

Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ischemic preconditioning during coronary artery bypass grafting Eva Kottenberg, MD, Judith Musiolik, PhD, Matthias Thielmann, MD, Heinz Jakob, MD, Jürgen Peters, MD, Gerd Heusch, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 147, Issue 1, Pages 376-382 (January 2014) DOI: 10.1016/j.jtcvs.2013.01.005 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Time course of serum cardiac troponin I (cTnI) before (preop) and 1, 6, 12, 24, 48, and 72 hours after coronary artery bypass grafting (mean ± standard deviation) with (black circles, n = 12) or without (open circles, n = 12) remote ischemic preconditioning (RIPC) under propofol anesthesia. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 376-382DOI: (10.1016/j.jtcvs.2013.01.005) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Comparison of phosphorylated (p) and total signal transducer and activator of transcription (STAT)5 content in left ventricular myocardial biopsy specimens obtained from patients with coronary artery disease undergoing remote ischemic preconditioning (RIPC) or not (no RIPC) under propofol anesthesia. A, original Western blot; and B, C, mean ± standard deviation. tyr, Tyrosine. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 376-382DOI: (10.1016/j.jtcvs.2013.01.005) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions