Bispectral index, serum drug concentrations and emergence associated with individually adjusted target-controlled infusions of remifentanil and propofol.

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Presentation transcript:

Bispectral index, serum drug concentrations and emergence associated with individually adjusted target-controlled infusions of remifentanil and propofol for laparoscopic surgery† S.C. Hoymork, J Raeder, B Grimsmo, P.A. Steen British Journal of Anaesthesia Volume 91, Issue 6, Pages 773-780 (December 2003) DOI: 10.1093/bja/aeg258 Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 1 Procedure for anaesthesia monitoring and stabilizing adjustment. The BIS values were kept within narrow limits by frequent adjustments of the propofol target. Blood pressure and heart rate were allowed to vary within wider limits. Adjustment of the remifentanil target was done only in order to avoid potentially serious side-effects. British Journal of Anaesthesia 2003 91, 773-780DOI: (10.1093/bja/aeg258) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 2 Estimated vs measured values of propofol. British Journal of Anaesthesia 2003 91, 773-780DOI: (10.1093/bja/aeg258) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 3 Estimated vs measured values of remifentanil. British Journal of Anaesthesia 2003 91, 773-780DOI: (10.1093/bja/aeg258) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 4 Measured values of propofol and corresponding BIS values. Open circles represent samples during the emergence phase when the patients responded to verbal command. Closed circles represent patients during anaesthesia. British Journal of Anaesthesia 2003 91, 773-780DOI: (10.1093/bja/aeg258) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 5 Measured values of propofol and corresponding BIS values in the desired range (BIS between 45 and 60). British Journal of Anaesthesia 2003 91, 773-780DOI: (10.1093/bja/aeg258) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions