Tissue/blood and tissue/water partition coefficients for propofol in sheep†‡  B.M.Q. Weaver, G.E. Staddon, W.W. Mapleson  British Journal of Anaesthesia  Volume 86, Issue 5, Pages 693-703 (May 2001) DOI: 10.1093/bja/86.5.693 Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 1 Concentrations of propofol in blood, corrected for loss in storage, plotted against time. Top: arterial concentrations in individual sheep of subgroup Pa, infused at 1 ml min–1. Bottom: mean of regression lines fitted (from 15 min onwards) to arterial (continuous line) and venous (broken lines) concentrations in each sheep of subgroup Pa, infused at 1 ml min–1, and to venous concentrations in each of those subgroup Pb sheep infused at 2 ml min–1. The slopes of the fitted lines are [mean (se)]: for subgroup Pa sheep infused at 1 ml min–1 (n=7, i.e. excluding ewe 37) 0.55 (0.21) and 0.55 (0.25) µg ml–1 h–1 for arterial and venous concentrations respectively; and, for subgroup Pb sheep infused at 2 ml min–1 (n=4, venous concentrations only), 3.4 (0.70) µg ml–1 h–1. The corresponding residual standard deviations were 0.72, 0.65 and 1.54 µg ml–1. British Journal of Anaesthesia 2001 86, 693-703DOI: (10.1093/bja/86.5.693) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions