Gabriel Loor, MD, Liang Li, PhD, Joseph F

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Presentation transcript:

Nadir hematocrit during cardiopulmonary bypass: End-organ dysfunction and mortality Gabriel Loor, MD, Liang Li, PhD, Joseph F. Sabik, MD, Jeevanantham Rajeswaran, MSc, Eugene H. Blackstone, MD, Colleen G. Koch, MD, MS, MBA The Journal of Thoracic and Cardiovascular Surgery Volume 144, Issue 3, Pages 654-662.e4 (September 2012) DOI: 10.1016/j.jtcvs.2012.03.058 Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Unadjusted patient outcomes associated with nadir hematocrit (Hct). Relationship represented by black solid line. Gray area indicates 95% point-wise confidence band. eGFR, Estimated glomerular filtration rate; ICU, intensive care unit. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 654-662.e4DOI: (10.1016/j.jtcvs.2012.03.058) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Adjusted relationship between nadir hematocrit (Hct) and outcomes from generalized propensity score analysis. Gray lines indicate the relationship within each patient strata defined by the generalized propensity score. Fifty strata were used, representing a spectrum of risk levels (except for all-cause death, for which we combined 50 strata into 5 to estimate the baseline survival probability accurately). Solid line indicates average across all strata. For comparison purposes, the dashed lines represent the same model between outcomes and nadir Hct without stratification. eGFR, Estimated glomerular filtration rate; ICU, intensive care unit. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 654-662.e4DOI: (10.1016/j.jtcvs.2012.03.058) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Predicted mean nadir hematocrit (Hct) based on regression model presented in Table 3. First 3 plots are predicted nadir Hct vs age, body mass index, and duration in minutes of cardiopulmonary bypass (CPB), stratified by gender (male, solid line; female, dashed line) and with all other predictors fixed at values corresponding to a middle-risk patient. The last plot is a box plot comparing nadir Hct and New York Heart Association (NYHA) functional class. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 654-662.e4DOI: (10.1016/j.jtcvs.2012.03.058) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Operative trends in hematocrit (Hct) values for the patient population. CPB, Cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 654-662.e4DOI: (10.1016/j.jtcvs.2012.03.058) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions