Pathogenesis of myeloproliferative neoplasms Radek C. Skoda, Adrian Duek, Jean Grisouard  Experimental Hematology  Volume 43, Issue 8, Pages 599-608 (August 2015) DOI: 10.1016/j.exphem.2015.06.007 Copyright © 2015 ISEH - International Society for Experimental Hematology Terms and Conditions

Figure 1 Frequency and distribution of acquired gene mutations in hematologic malignancies. The red portions of the horizontal bars indicate the approximate frequencies of the mutations in the different disease entities. ALL = acute lymphocytic leukemia; AML = acute myeloid leukemia; CML = chronic myeloid leukemia; CNL = chronic neutrophilic leukemia; ET = essential thrombocythemia; MDS = myelodysplastic syndromes; MPN = myeloproliferative neoplasms; PMF = primary myelofibrosis; PV = polycythemia vera; RARS-T = refractory anemia with ring sideroblasts and thrombocytosis; sAML = secondary acute myeloid leukemia. Experimental Hematology 2015 43, 599-608DOI: (10.1016/j.exphem.2015.06.007) Copyright © 2015 ISEH - International Society for Experimental Hematology Terms and Conditions

Figure 2 (A) Domain structure of the Jak2 protein. Numbers indicate amino acid positions within the Jak2 protein. Arrows indicate the positions of the most frequently mutated regions. The auto-inhibitory effect of the JH2 domain is indicated in yellow. FERM = N-terminal Band 4.1, ezrin, radixin, moesin domain; JH1 and JH2 = Jak homology 1 and 2 domains; SH2 = Src homology 2 domain. (B) Model of the interactions between the domains of the Jak2 protein bound to the erythropoietin receptor (EpoR). F = FERM domain; K = kinase domain (JH1); SH = SH2 domain. Experimental Hematology 2015 43, 599-608DOI: (10.1016/j.exphem.2015.06.007) Copyright © 2015 ISEH - International Society for Experimental Hematology Terms and Conditions

Figure 3 Model summarizing the known and hypothetical roles of Stat proteins in erythropoiesis and megakaryopoiesis in mice expressing JAK2-V617F. Arrows indicate stimulatory effects; T-Bars indicate inhibitory effects. Epo = erythropoietin; EpoR = erythropoietin receptor; Mpl = thrombopoietin receptor; Tpo = thrombopoietin. Experimental Hematology 2015 43, 599-608DOI: (10.1016/j.exphem.2015.06.007) Copyright © 2015 ISEH - International Society for Experimental Hematology Terms and Conditions