Proteomic approach in the search of new cardiovascular biomarkers

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Proteomic approach in the search of new cardiovascular biomarkers Julio Gallego-Delgado, Alberto Lazaro, Julio J. Osende, Maria M. Barderas, Luis L. Blanco-Colio, Maria Carmen Duran, Jose J. Martin- Ventura, Fernando Vivanco, Jesus Egido Kidney International Volume 68, Pages S103-S107 (December 2005) DOI: 10.1111/j.1523-1755.2005.09919.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 (A) Representative image of 2-DE gel from left ventricular samples, showing 15 altered protein spots (squares) compared with normal heart. As an example, we show the identification of one of these altered proteins (arrow). (B) Peptide mass fingerprint spectrum was obtained on a Bruker Ultraflex TOF/TOF MALDI mass spectrometer (Bruker-Daltonics GmbH, Bremen, Germany). (C) The measured tryptic peptide masses were transferred through the MS BioTools program (Bruker-Daltonics) as inputs to search the MSBD database using Mascot software (Matrix Science, London, UK). This spot protein was positively identified as mitochondrial adenosine triphosphate synthase D chain. Kidney International 2005 68, S103-S107DOI: (10.1111/j.1523-1755.2005.09919.x) Copyright © 2005 International Society of Nephrology Terms and Conditions