Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before.

Slides:

Advertisements

Similar presentations

F. Chung, R. Subramanyam, P. Liao, E. Sasaki, C. Shapiro, Y. Sun

Advertisements

E.M. Wesselink, T.H. Kappen, H.M. Torn, A.J.C. Slooter, W.A. van Klei

M.E. Jørgensen, C. Andersson, S. Venkatesan, R.D. Sanders

Benefits and risks of epidural analgesia in cardiac surgery†

Randomized controlled trial of stroke volume optimization during elective major abdominal surgery in patients stratified by aerobic fitness C.W. Lai,

N-terminal pro B-type natriuretic peptide is an independent predictor of postoperative myocardial injury in patients undergoing major vascular surgery

Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults Y. Zhang, G.-J. Shan,

Efficacy and adverse effects of buprenorphine in acute pain management: systematic review and meta-analysis of randomised controlled trials L.D. White,

N-terminal fragment of pro-B-type natriuretic peptide is a predictor of cardiac events in high-risk patients undergoing acute hip fracture surgery A.

Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized,

Management of antiplatelet therapy in patients with coronary stents undergoing noncardiac surgery: association with adverse events A. Rodriguez, N. Guilera,

Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol–remifentanil total i.v. anaesthesia with desflurane anaesthesia

Lidocaine use in ultrasound-guided femoral nerve block: what is the minimum effective anaesthetic concentration (MEAC90)?† A.M. Taha, A.M. Abd-Elmaksoud

K.-Y. Ho, W Tay, M.-C. Yeo, H Liu, S.-J. Yeo, S.-L. Chia, N.-N. Lo

Effect of combining tramadol and morphine in adult surgical patients: a systematic review and meta-analysis of randomized trials V. Martinez, L. Guichard,

D. M. Baron, H. Hochrieser, M. Posch, B. Metnitz, A. Rhodes, R. P

Frequency of surgical treatment and related hospital procedures in the UK: a national ecological study using hospital episode statistics T.E.F. Abbott,

High concentrations of N-BNP are related to non-infectious severe SIRS associated with cardiovascular dysfunction occurring after off-pump coronary artery.

Cost-effectiveness of a systematic e-assessed follow-up of postoperative recovery after day surgery: a multicentre randomized trial K. Dahlberg, A. Philipsson,

G. L. Ackland, T. E. F. Abbott, R. M. Pearse, S. N. Karmali, J

Injuries associated with anaesthesia. A global perspective

Plasma N-terminal pro-B-type natriuretic peptide as a predictor of perioperative and long-term outcome after vascular surgery Olaf Schouten, MD, Sanne.

Preoperative abnormalities in serum sodium concentrations are associated with higher in-hospital mortality in patients undergoing major surgery M. Cecconi,

Changes in glomerular filtration rate after cardiac surgery with cardiopulmonary bypass in patients with mild preoperative renal dysfunction B.G. Loef,

Perioperative myocardial injury in patients receiving cardiac output-guided haemodynamic therapy: a substudy of the OPTIMISE Trial M.A. Gillies, A.S.V.

Randomised trial comparing forced-air warming to the upper or lower body to prevent hypothermia during thoracoscopic surgery in the lateral decubitus.

Perioperative statin therapy in patients at high risk for cardiovascular morbidity undergoing surgery: a review B.A. de Waal, M.P. Buise, A.A.J. van.

N-terminal pro-B-type natriuretic peptide concentrations and long-term outcome after cardiac surgery: a prospective cohort study B.H. Cuthbertson, B.L.

N-terminal pro B-type natriuretic peptide (NT pro-BNP) is a predictor of long-term survival in male patients of 75 years and older with high-grade asymptomatic.

Preoperative heart rate and myocardial injury after non-cardiac surgery: results of a predefined secondary analysis of the VISION study T.E.F. Abbott,

J.-Y. Hwang, H.-S. Na, Y.-T. Jeon, Y.-J. Ro, C.-S. Kim, S.-H. Do

Comparison of oxygen uptake during arm or leg cardiopulmonary exercise testing in vascular surgery patients and control subjects L. Loughney, M. West,

Role of N-terminal pro B-type natriuretic peptide in identifying patients at high risk for adverse outcome after emergent non-cardiac surgery S. Farzi,

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries British Journal of Anaesthesia

Preoperative supplementation with fibrinogen concentrate in cardiac surgery: A randomized controlled study A. Jeppsson, K. Waldén, C. Roman-Emanuel,

Pain after orthopaedic surgery: differences in patient reported outcomes in the United States vs internationally. An observational study from the PAIN.

Measuring non-technical skills of anaesthesiologists in the operating room: a systematic review of assessment tools and their measurement properties

Preadmission statin use improves the outcome of less severe sepsis patients - a population-based propensity score matched cohort study M.G. Lee, C.-C.

M. O'Hare, Y. Maldonado, J. Munro, M. J. Ackerman, H. Ramakrishna, D

Effect of patient sex on general anaesthesia and recovery

Volume 71, Issue 6, Pages (March 2007)

Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional.

Steroids in cardiac surgery: a systematic review and meta-analysis

H. J. Kim, H. -C. Lee, Y. S. Jung, J. Lee, J. J. Min, D. -M. Hong, E

Impact of preoperative serum creatinine on short- and long-term mortality after cardiac surgery: a cohort study M.H. Bernardi, D. Schmidlin, A. Schiferer,

Association between mode of anaesthesia and severe maternal morbidity during admission for scheduled Caesarean delivery: a nationwide population-based.

Comparison of the effects of albumin 5%, hydroxyethyl starch 130/0

Comparative study of topical anaesthesia with lidocaine 2% vs levobupivacaine 0.75% in cataract surgery S.A. Fernández, E. Dios, J.C. Diz British Journal.

A. Mekontso-Dessap, L. Tual, M. Kirsch, G. D'Honneur, D. Loisance, L

Defining oliguria during cardiopulmonary bypass and its relationship with cardiac surgery–associated acute kidney injury D. Hori, N.M. Katz, D.M. Fine,

Perioperative administration of fibrinogen does not increase adverse cardiac and thromboembolic events after cardiac surgery J. Fassl, G. Lurati Buse,

D. Fletcher, V. Martinez British Journal of Anaesthesia

Preoperative evaluation of patients with, or at risk of, coronary artery disease undergoing non-cardiac surgery P.-G. Chassot, A. Delabays, D.R. Spahn

Troponin elevations after non-cardiac, non-vascular surgery are predictive of major adverse cardiac events and mortality: a systematic review and meta-analysis

Incidence, characteristics, and predictive factors for medication errors in paediatric anaesthesia: a prospective incident monitoring study C. Gariel,

EuroSCORE II and N-terminal pro-B-type natriuretic peptide for risk evaluation: an observational longitudinal study in patients undergoing coronary artery.

C. J. Payne, S. C. Gibson, G. Bryce, A. G. Jardine, C. Berry, D. B

Volatile compared with total intravenous anaesthesia in patients undergoing high-risk cardiac surgery: a randomized multicentre study G. Landoni, F.

Patients’ inability to perform a preoperative cardiopulmonary exercise test or demonstrate an anaerobic threshold is associated with inferior outcomes.

Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery C. Solomon,

E. -H. Lee, H. -M. Lee, C. -H. Chung, J. -H. Chin, D. -K. Choi, H. -J

T. Mizota, Y. Yamamoto, M. Hamada, S. Matsukawa, S. Shimizu, S. Kai

Increase in endogenous erythropoietin synthesis through the normobaric oxygen paradox in cardiac surgery patients Y. Ciccarella, C. Balestra, J. Valsamis,

Validity of the 6 min walk test in prediction of the anaerobic threshold before major non- cardiac surgery R.C.F. Sinclair, A.M. Batterham, S. Davies,

Systematic review of the QoR-15 score, a patient- reported outcome measure measuring quality of recovery after surgery and anaesthesia J. Kleif, J. Waage,

Effect of preoxygenation using non-invasive ventilation before intubation on subsequent organ failures in hypoxaemic patients: a randomised clinical trial

Levosimendan pre-treatment improves outcomes in patients undergoing coronary artery bypass graft surgery† L. Tritapepe, V. De Santis, D. Vitale, F. Guarracino,

D Frasca, C Dahyot-Fizelier, W Couet, B Debaene, O Mimoz, S Marchand

N-terminal pro-B-type natriuretic peptide levels and early outcome after cardiac surgery: a prospective cohort study B.H. Cuthbertson, B.L. Croal, D.

R. Parke, S. McGuinness, R. Dixon, A. Jull

Presentation transcript:

Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before surgery study T.E.F. Abbott, R.M. Pearse, B.H. Cuthbertson, D.N. Wijeysundera, G.L. Ackland British Journal of Anaesthesia Volume 122, Issue 2, Pages 188-197 (February 2019) DOI: 10.1016/j.bja.2018.10.060 Copyright © 2018 The Author(s) Terms and Conditions

Fig 1 Patient flow diagram showing the number of patients included in the analysis. CPET, cardiopulmonary exercise testing. British Journal of Anaesthesia 2019 122, 188-197DOI: (10.1016/j.bja.2018.10.060) Copyright © 2018 The Author(s) Terms and Conditions

Fig 2 Heart rate recovery 1 min after the end of exercise. Histogram showing the frequency distribution of heart rate recovery 1 min after the end of exercise in beats min−1. British Journal of Anaesthesia 2019 122, 188-197DOI: (10.1016/j.bja.2018.10.060) Copyright © 2018 The Author(s) Terms and Conditions

Fig 3 Heart rate recovery and Revised Cardiac Risk Index (RCRI). Bar charts showing (a) the proportion (%) of participants with heart rate recovery (HRR) less than or equal to 12 beats min−1, and (b) mean heart rate recovery (beats min−1), stratified by the RCRI. Error bars indicate the 95% confidence interval for the mean. Overall, 167/419 patients with RCRI=0 had heart rate recovery ≤12 beats min−1, 355/871 patients with RCRI=1–2 had heart rate recovery ≤12 beats min−1, and 26/36 patients with RCRI ≥3 had heart rate recovery ≤12 beats min−1. The proportion of patients with heart rate recovery ≤12 beats min−1 was significantly greater for RCRI ≥3 compared with the other two groups (P<0.01). British Journal of Anaesthesia 2019 122, 188-197DOI: (10.1016/j.bja.2018.10.060) Copyright © 2018 The Author(s) Terms and Conditions

Fig 4 Heart rate recovery and NT Pro-BNP. Bar charts showing (a) the proportion (%) of participants with heart rate recovery ≤12 beats min−1, and (b) mean heart rate recovery (beats min−1), stratified by NT pro-BNP concentration (<100, 100–199, and ≥200 pg ml−1). Error bars indicate the 95% confidence interval for the mean. Overall, 263/719 (36.6%) patients with NT pro-BNP <100 pg ml−1 had heart rate recovery ≤12 beats min−1, 119/291 (40.9%) patients with NT pro-BNP 100–199 pg ml−1 had heart rate recovery ≤12 beats min−1, and 146/263 (55.5%) patients with NT pro-BNP ≥200 pg ml−1 had heart rate recovery ≤12 beats min−1. NT Pro-BNP, N-terminal pro-hormone of brain natriuretic peptide. British Journal of Anaesthesia 2019 122, 188-197DOI: (10.1016/j.bja.2018.10.060) Copyright © 2018 The Author(s) Terms and Conditions