Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before.

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Presentation transcript:

Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before surgery study  T.E.F. Abbott, R.M. Pearse, B.H. Cuthbertson, D.N. Wijeysundera, G.L. Ackland  British Journal of Anaesthesia  Volume 122, Issue 2, Pages 188-197 (February 2019) DOI: 10.1016/j.bja.2018.10.060 Copyright © 2018 The Author(s) Terms and Conditions

Fig 1 Patient flow diagram showing the number of patients included in the analysis. CPET, cardiopulmonary exercise testing. British Journal of Anaesthesia 2019 122, 188-197DOI: (10.1016/j.bja.2018.10.060) Copyright © 2018 The Author(s) Terms and Conditions

Fig 2 Heart rate recovery 1 min after the end of exercise. Histogram showing the frequency distribution of heart rate recovery 1 min after the end of exercise in beats min−1. British Journal of Anaesthesia 2019 122, 188-197DOI: (10.1016/j.bja.2018.10.060) Copyright © 2018 The Author(s) Terms and Conditions

Fig 3 Heart rate recovery and Revised Cardiac Risk Index (RCRI). Bar charts showing (a) the proportion (%) of participants with heart rate recovery (HRR) less than or equal to 12 beats min−1, and (b) mean heart rate recovery (beats min−1), stratified by the RCRI. Error bars indicate the 95% confidence interval for the mean. Overall, 167/419 patients with RCRI=0 had heart rate recovery ≤12 beats min−1, 355/871 patients with RCRI=1–2 had heart rate recovery ≤12 beats min−1, and 26/36 patients with RCRI ≥3 had heart rate recovery ≤12 beats min−1. The proportion of patients with heart rate recovery ≤12 beats min−1 was significantly greater for RCRI ≥3 compared with the other two groups (P<0.01). British Journal of Anaesthesia 2019 122, 188-197DOI: (10.1016/j.bja.2018.10.060) Copyright © 2018 The Author(s) Terms and Conditions

Fig 4 Heart rate recovery and NT Pro-BNP. Bar charts showing (a) the proportion (%) of participants with heart rate recovery ≤12 beats min−1, and (b) mean heart rate recovery (beats min−1), stratified by NT pro-BNP concentration (<100, 100–199, and ≥200 pg ml−1). Error bars indicate the 95% confidence interval for the mean. Overall, 263/719 (36.6%) patients with NT pro-BNP <100 pg ml−1 had heart rate recovery ≤12 beats min−1, 119/291 (40.9%) patients with NT pro-BNP 100–199 pg ml−1 had heart rate recovery ≤12 beats min−1, and 146/263 (55.5%) patients with NT pro-BNP ≥200 pg ml−1 had heart rate recovery ≤12 beats min−1. NT Pro-BNP, N-terminal pro-hormone of brain natriuretic peptide. British Journal of Anaesthesia 2019 122, 188-197DOI: (10.1016/j.bja.2018.10.060) Copyright © 2018 The Author(s) Terms and Conditions