M. Bojan, S. Vicca, C. Boulat, S. Gioanni, P. Pouard

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Presentation transcript:

Aprotinin, transfusions, and kidney injury in neonates and infants undergoing cardiac surgery M. Bojan, S. Vicca, C. Boulat, S. Gioanni, P. Pouard British Journal of Anaesthesia Volume 108, Issue 5, Pages 830-837 (May 2012) DOI: 10.1093/bja/aes002 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 Patient enrolment process over a 42 month period. Aprotinin was suspended from prophylactic use starting in the 20th month. Patients with missing data concerning transfusion and/or CPB characteristics and/or postoperative creatinine measurements were excluded. British Journal of Anaesthesia 2012 108, 830-837DOI: (10.1093/bja/aes002) Copyright © 2012 The Author(s) Terms and Conditions

Fig 2 Number of blood product transfusions and CPB priming volumes across the study period. Data are shown as means and sd. There was a significant decrease in all blood product transfusions and in priming volumes over time, as shown by the results of analysis of variance, all P-values <0.001. Day 0: the day of surgery. British Journal of Anaesthesia 2012 108, 830-837DOI: (10.1093/bja/aes002) Copyright © 2012 The Author(s) Terms and Conditions

Fig 3 Incidence of AKI and of AKI requiring PD across the study period. There was no linear trend for the overall AKI incidence, χ2 P-value=0.77, and the incidence of PD increased, χ2 P-value=0.02. British Journal of Anaesthesia 2012 108, 830-837DOI: (10.1093/bja/aes002) Copyright © 2012 The Author(s) Terms and Conditions