Institute of Food Research IFR FORWARD OPEN DAY September 2006

2 Gut Biology Nutrition, Diet & Health Molecular Microbiology Food Biophysics IFR Science Skills Base

3 Gut Biology Understanding gut health and function Good Guys 11 Eat for Life 5

4 Gut Biology Nutrition, Diet & Health A volunteers life How our diet influences our long-term health Human Nutrition Unit 11

Obesity Trends* Among U.S. Adults BRFSS, 1985 No Data <10% 10%–14% Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% Obesity Trends* Among U.S. Adults BRFSS, 1986 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% Obesity Trends* Among U.S. Adults BRFSS, 1987 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% Obesity Trends* Among U.S. Adults BRFSS, 1988 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% Obesity Trends* Among U.S. Adults BRFSS, 1989 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% Obesity Trends* Among U.S. Adults BRFSS, 1990 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% Obesity Trends* Among U.S. Adults BRFSS, 1991 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% Obesity Trends* Among U.S. Adults BRFSS, 1992 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% Obesity Trends* Among U.S. Adults BRFSS, 1993 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% Obesity Trends* Among U.S. Adults BRFSS, 1994 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% Obesity Trends* Among U.S. Adults BRFSS, 1995 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% Obesity Trends* Among U.S. Adults BRFSS, 1996 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% 20 Obesity Trends* Among U.S. Adults BRFSS, 1997 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% 20 Obesity Trends* Among U.S. Adults BRFSS, 1998 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% 20 Obesity Trends* Among U.S. Adults BRFSS, 1999 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% 20 Obesity Trends* Among U.S. Adults BRFSS, 2000 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% 20%–24% 25% Obesity Trends* Among U.S. Adults BRFSS, 2001 Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14% 15%–19% 20%–24% 25% Obesity Trends* Among U.S. Adults BRFSS, 2002 Source: Behavioral Risk Factor Surveillance System, CDC

23 Gut Biology Nutrition, Diet & Health Molecular Microbiology Understanding and controlling bacterial foodborne pathogens Good Guys 11 Bad guys 10,15

24 Gut Biology Nutrition, Diet & Health Molecular Microbiology Food Biophysics Maintaining food quality with a healthy diet Feelgood foods oil 7

25 Gut Biology Nutrition, Diet & Health Molecular Microbiology Food Biophysics Gut IFR Science Skills Base

26 New Research Leaders Systems Biology Gut Biology Molecular Immunology Molecular nutrition

27 omics Transcriptomics – microarrays Proteomics Metabolomics Imaging TEM, SEM, Light Microscopy Nmr Atomic Force Microscopy IFR Technology Skills Base Oh Me, Oh my – omics and Wheres Wally 3 2

28 Exploitation Platforms Sustainability of food chainKeith Waldron Magnetic Resonance ImagingBrian Hills Model GutMartin Wickham National Collection of Yeast Cultures Ian Roberts Food DatabanksPaul Finglas Microbial EcologyTim Brocklehurst

29 Facilitates a knowledge-based industry Helps develops relationships between IFR and its industry stakeholders that bring mutual benefits Cost-effective knowledge-sharing - promoting an environment where food Industry professionals can network with research scientists

30 Activities Regular Cluster meetings on relevant topics Cross-cluster meetings on areas of more general interest at locations convenient to industry (North and South). Proposed topics now available on FHN stand FHN Direct: 1:1 consultations on confidential basis at IFR or on-site

31 The Clusters & their Leaders Allergy – Clare Mills Co-product exploitation – Keith Waldron Food Structure & Nutrition – Pete Wilde Pathways to personalised nutrition – Siân Astley Predictive Microbiology & Risk Analysis – Jòzsef Baranyi Quality throughout Shelf-Life – Reg Wilson

32 Food & Health Network Direct One-to-one collaboration with the food industry Your issues – our complementary skills

33 Norwich Research Park IFR UEA Triangle JIC Hospital NNUH UEA Main Campus PBL UEA Institute of Health Medical School Computer Science Chemistry & Pharmacy Biology PBL Licensing Patent Protection Market Research NNUH Clinicians within IFR Histo-pathology Tissue Bank Numerous depts You are here John Innes Centre Plant/microbe genetics Crop development

34 European Agenda Member of Initiative Group (with Wageningen and Unilever) for development of a vision document for a European Technology Platform: Food for Life Food and Health Food Quality and Manufacturing Consumer and the integrated food chain

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36 omics Transcriptomics – microarrays Proteomics Metabolomics Imaging TEM, SEM, Light Microscopy Nmr Atomic Force Microscopy Bioinformatics Statistics Modelling High-throughput analysis Human Nutrition Unit National Collection of Yeast Cultures IFR Technology Skills Base 8 12

37 Strategic Plan: Vision and Mission Mission Undertake international quality scientific research relevant to food and human health Work in partnership with others to provide underpinning science for consumers, policy makers, the food industry and academia Vision to be a world-leading contributor to harnessing food for health and controlling food-related disease

38 IFR The Institute of Food Research (IFR) is a not-for- profit company with charitable status Sponsored by the Biotechnology & Biological Sciences Research Council IFR and IFR Enterprises Ltd are registered to the quality standard ISO 9001

39 Strategic Plan: Objectives Gastrointestinal Tract Biology: Understanding gut health and function Nutrition, Diet and Health: Understanding how our diet influences our long-term health Food Innovation: Maintaining food quality with a healthy diet Food Safety: Understanding and controlling bacterial foodborne pathogens

40 IFR Turnover ~ £15m pa 190 scientific staff, 18 PhD students Admin Support joint with JIC 9.1

41 Outputs High-quality science base Research papers Underpinning evidence for policy – especially for Government (FSA, Defra, DH) Influence on policy Knowledge Transfer – especially for industry Collaboration Licensing, spin-outs etc

42 GI Tract Biology Nutrition Diet & Health Food Innovation Food Safety Mass Spectrometry Metabolomics Functional Genomics Human Nutrition Unit Atomic Force Microscopy Confocal SEM, TEM FTIR Animal Facilities Basic Science Micro- biologists Bio- chemists Analytical Chemists Physicists Physiol- ogists Physical Chemists Plant Scientists Nutritionists Social Scientists Mathemat- icians

43 GI Tract Biology Nutrition Diet & Health Food Innovation Food Safety Mass Spectrometry Metabolomics Functional Genomics Human Nutrition Unit Atomic Force Microscopy Confocal SEM, TEM FTIR Animal Facilities Micro- biologists Bio- chemists Analytical Chemists Physicists Physiol- ogists Physical Chemists Plant Scientists Nutritionists Social Scientists Mathemat- icians Allergy Obesity Emerging Pathogens Microbiol safety of the food chain Waste / Sustainability Bioterrorism Ageing Population Quality in the food chain Diet and Disease Strategic Relevance

44 GI Tract Biology Nutrition Diet & Health Food Innovation Food Safety Mass Spectrometry Metabolomics Functional Genomics Human Nutrition Unit Atomic Force Microscopy Confocal SEM, TEM FTIR Animal Facilities Micro- biologists Bio- chemists Analytical Chemists Physicists Physiol- ogists Physical Chemists Plant Scientists Nutritionists Social Scientists Mathemat- icians ClostridiaGM identity Authenticity Micronutrient deficiency Pathogen Elimination GM and Novel Foods Colon Health FSA

45 Influence on policy The institute has made important contributions to the development of UK policy on e.g.: Dietary fibre (throughout the 1990s) Fruits and vegetables (development of 5-a-day advice ) n-3 fatty acid consumption (from fish ) Mineral nutrition (1990s and 2000s) Colonic health (late 1990s) Shelf-life of chilled foods (2000s)

46 Delivery Programmes Partnerships Exploitation Platforms

47 Programmes Shortform titleProg Leader GI tract biology and healthIan Johnson Commensals & microfloraMike Gasson Phytochemicals & HealthRichard Mithen MicronutrientsSue F-Tait Personalised (mol) Nutritionto be appointed Structuring foods for healthClare Mills Pathogens: mol microbiolJay Hinton Pathogens: Phys & Pred EcolMike Peck

48 Internal Partnerships Bioinformatics and statistics Kate Kemsley Technologies for Systems Biology Transcriptomics Tony Michael Proteomics Metabolomics Risk & Consumer ScienceNigel Lambert Imaging Vic Morris [Support Units] [HNU, North Site UEA]

49 Research Collaborations Our scientific research collaboration stretches across the world through informal and formal partnerships. Examples:

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51 Molecular Microbiology

52 Nutrition, Diet and Health

Obesity Body Mass Index (BMI): a measure of an adults weight in relation to height, specifically the adults weight in kilograms divided by the square of his or her height in meters. Obesity: having a very high amount of body fat in relation to lean body mass, or Body Mass Index (BMI) of 30 or higher. Overweight: a BMI between 25 and 30.

Case 2: Obesity

55 Gut Biology

56 Norwich Research Park IFR UEA Triangle JIC Hospital NNUH UEA Main Campus PBL UEA Institute of Health Medical School Computer Science Chemistry & Pharmacy Biology PBL Licensing Patent Protection Market Research NNUH Clinicians within IFR Histo-pathology Tissue Bank Numerous depts Sainsbury Laboratory You are here

57 Gut Biology Nutrition, Diet & Health Molecular Microbiology Food Biophysics IFR Skills Base

58 Functional Genomics / Systems Biology Genome Sequences Pathogens Salmonella enterica Campylobacter jejuni Clostridium botulinum Commensals Lactococcus lactis Lactobacillus johnsonii Bifidobacterium breve L. Lactis MG1363

59 Bacterial IFR 2006 SALSA 4 Salmonella serovars 5600 genes ShE. Coli 6500 genes E. coli O157 & Shigella flexneri EPEC/ ETEC virulence genes Campylobacter jejuni 1800 genes, plus plasmids Clostridium botulinum 3456 genes Lactococcus lactis 2587 genes Coming soon: Bifidobacterium breve Lactobacillus johnsonii

Salmonella Compendium Database 1.0 Macs 4,8,12h HeLa 2,4,6h hns pH3.0 hilACD MM-low glucose ATR pH5.5 phoP

SPI1 caught napping? Hierarchical clustering of EnviCom SPI1 genes cluster with 5 nap genes A co-regulatory mechanism? Do the nap genes play a role in invasion? napFDHBC SPI1

Gut Biology Nutrition, Diet & Health Molecular Microbiology Food Biophysics IFR Skills Base