Capturing echocardiographic allograft valve function over time after allograft aortic valve or root replacement M. Mostafa Mokhles, PhD, MSc, Jeevanantham.

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Presentation transcript:

Capturing echocardiographic allograft valve function over time after allograft aortic valve or root replacement M. Mostafa Mokhles, PhD, MSc, Jeevanantham Rajeswaran, MSc, Jos A. Bekkers, MD, Gerard J.J.M. Borsboom, MSc, Jolien W. Roos- Hesselink, MD, PhD, Ewout W. Steyerberg, PhD, Ad J.J.C. Bogers, MD, PhD, Johanna J.M. Takkenberg, MD, PhD, Eugene H. Blackstone, MD The Journal of Thoracic and Cardiovascular Surgery Volume 148, Issue 5, Pages 1921-1928.e3 (November 2014) DOI: 10.1016/j.jtcvs.2014.04.023 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Competing risks of outcomes. Prevalence of death (red) and reoperation (blue) at each moment in time of patients in each of mutually exclusive categories in the overall group. Parametric estimates enclosed within 95% confidence limits show patient mortality (in red), reoperation (in blue), and patients being alive and not undergoing reoperation (green). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1921-1928.e3DOI: (10.1016/j.jtcvs.2014.04.023) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Temporal trend of AR after the procedure (grade 0 = green, grade 1+ = blue, grade 2+ = orange, grade 3+/4+ = red). Solid lines represent percentage of patients (mean effect) in each grade at various time points. Symbols represent crude estimates of grouped raw data without regard to repeated measures and are presented to verify the model fitting. AR, Aortic regurgitation. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1921-1928.e3DOI: (10.1016/j.jtcvs.2014.04.023) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Solid lines are parametric estimates of mean aortic gradient from nonlinear longitudinal mixed model and are enclosed within dashed 95% bootstrap percentile confidence bands, equivalent to 2 standard deviations. Symbols represent crude estimates of grouped raw data without regard to repeated measures and are presented to verify the model fitting. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1921-1928.e3DOI: (10.1016/j.jtcvs.2014.04.023) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Instantaneous risks of death (red) and reoperation (blue) (hazard function). Solid lines are parametric estimates enclosed within 95% confidence limits. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1921-1928.e3DOI: (10.1016/j.jtcvs.2014.04.023) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E2 Predicted percentages of patients in AR grade 3+/4+ stratified by operative technique (subcoronary = red; root replacement = blue). Symbols represent crude estimates of grouped raw data without regard to repeated measures and are presented to verify the model fitting. AR, Aortic regurgitation. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1921-1928.e3DOI: (10.1016/j.jtcvs.2014.04.023) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E3 Fifteen-year predicted percentages of patients in AR grade 3+/4+ by age, stratified by operative technique (subcoronary = red; root replacement = blue). Symbols represent crude estimates of grouped raw data without regard to repeated measures and are presented to verify the model fitting. AR, Aortic regurgitation. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1921-1928.e3DOI: (10.1016/j.jtcvs.2014.04.023) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E4 Fifteen-year predicted mean aortic gradient by age, stratified by operative techniques (subcoronary = red; root replacement = blue). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1921-1928.e3DOI: (10.1016/j.jtcvs.2014.04.023) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E5 Solid lines are parametric estimates of mean annulus diameter from nonlinear longitudinal mixed model and are enclosed within dashed 95% bootstrap percentile confidence bands, equivalent to 2 standard deviations. Symbols represent crude estimates of grouped raw data without regard to repeated measures and are presented to verify the model fitting. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1921-1928.e3DOI: (10.1016/j.jtcvs.2014.04.023) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E6 Fifteen-year predicted mean of annulus diameter, stratified by operative technique (subcoronary = red; root replacement = blue). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1921-1928.e3DOI: (10.1016/j.jtcvs.2014.04.023) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E7 Solid lines are parametric estimates of mean LVOT diameter from nonlinear longitudinal mixed model and are enclosed within dashed 95% bootstrap percentile confidence bands, equivalent to 2 standard deviations. Symbols represent crude estimates of grouped raw data without regard to repeated measures and are presented to verify the model fitting. LVOT, Left ventricular outflow tract. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1921-1928.e3DOI: (10.1016/j.jtcvs.2014.04.023) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E8 Solid lines are parametric estimates of mean aortic diameter from nonlinear longitudinal mixed model and are enclosed within dashed 95% bootstrap percentile confidence bands, equivalent to 2 standard deviations. Symbols represent crude estimates of grouped raw data without regard to repeated measures and are presented to verify the model fitting. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1921-1928.e3DOI: (10.1016/j.jtcvs.2014.04.023) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions