SCUF Slow Continuous Ultrafiltration

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Presentation transcript:

SCUF Slow Continuous Ultrafiltration Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Blood is circulated through a semi permeable haemofilter via an extracorporeal circuit. Plasma water is pulled from the patients blood and into the waste/filtration bag by ultrafiltration. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved. Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Ultrafiltration The movement of fluid across a semi-permeable membrane with a hydrostatic pressure. A pressure gradient is created in the filter by the blood pump, producing a positive pressure within the individual fibres. The filtrate pump controls and regulates the convective flow of plasma water. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved. Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved. Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Primary Indications Fluid overload Severe oedema Congestive heart failure Fluid volume management Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved. Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

CVVHDF Continuous Veno-Venous Haemodiafiltration Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Blood is circulated through a highly permeable haemofilter via an extracorporeal circuit. Plasma water, water soluble small, middle, and large molecules are removed from the patients blood by ultrafiltration and convection. Also, small solutes diffuse from the patients blood into a dialysate solution. Some fluid is replaced into the patients blood to achieve the desired fluid balance. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved. Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Diffusion and Convection The movement of solutes across a semi-permeable membrane through a concentration gradient. The movement of fluid across a semi-permeable membrane creating solute drag. As fluid is pulled across the membrane solutes dissolved in the fluid are taken with it. Small, middle, and large sized water soluble molecules are removed. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved. Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved. Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Primary Indications Acute Kidney Injury Management of electrolytes Fluid volume management Small, middle, and large molecule removal targets Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

CVVHD Continuous Veno-venous Haemodialysis Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Blood is circulated through a highly permeable haemofilter or dialyser via an extracorporeal circuit. Water soluble small molecules diffuse out of the patients blood and into the dialysate solution, or out of the dialysate solution and into the patients blood. e.g. electrolytes Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Diffusion The movement of solutes across a semi-permeable membrane through a concentration gradient. Water soluble small molecules are removed. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Primary Indications Acute Kidney Injury Management of electrolytes Fluid volume management Small molecule removal targets Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

CVVH Continuous Veno-Venous Haemofiltration Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Blood is circulated through a highly permeable haemofilter via an extracorporeal circuit. Plasma water, small, middle, and large molecules are pulled from the patients blood and into the waste/filtration bag by ultrafiltration and convection (solute drag). Fluid is replaced into the patients blood at an equal or lower rate to achieve desired fluid loss. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Convection The movement of fluid across a semi-permeable membrane creating solute drag. As fluid is pulled across the membrane water soluble molecules dissolved in the fluid are taken with it. Small, middle, and large molecules are removed. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Primary Indications Acute Kidney Injury Management of electrolytes Fluid volume management Sepsis and septic shock Small, middle, and large molecule removal targets Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital TPE Therapeutic Plasma Exchange Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Plasma, small, middle and large sized molecules are Blood is circulated through a highly permeable plasmafilter via an extracorporeal circuit. Plasma, small, middle and large sized molecules are pulled from the patients blood and into the waste/filtration bag by ultrafiltration and convection. (solute drag) Plasma is replaced into the patients blood at an equal rate. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Convection The movement of fluid across a semi-permeable membrane creating solute drag. As fluid is pulled across the membrane, some plasma and other soluble components dissolved in the fluid are taken with it. Small, middle, and large molecules are removed. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Primary Indications Plasma replacement Plasma supplementation Individual Clinical Presentations Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

CVVH Continuous Veno-Venous Haemofiltration Regional Citrate Anticoagulation Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Plasma water, small, middle, and large sized solutes Blood is circulated through a highly permeable haemofilter via an extracorporeal circuit. Plasma water, small, middle, and large sized solutes are pulled from the patients blood and into the waste/filtration bag by ultrafiltration and convection. (solute drag) Fluid is replaced into the patients blood at an equal or lower rate to achieve desired fluid loss. The extracorporeal circuit only is anticoagulated. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Convection The movement of fluid across a semi-permeable membrane creating solute drag. As fluid is pulled across the membrane water soluble molecules dissolved in the fluid are taken with it Small, middle, and large molecules are removed. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Primary Indications Acute Renal Failure Management of electrolytes Management of fluid volume Small, middle, and large molecule removal targets Regional Citrate Anticoagulation is available Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital TPE Therapeutic Plasma Exchange Regional Citrate Anticoagulation Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Plasma is replaced into the patients blood at an equal rate. Blood is circulated through a highly permeable plasmafilter via an extracorporeal circuit. Plasma, small, middle, and large molecules are pulled from the patients blood and into the waste/filtration bag by ultrafiltration and convection. (solute drag) Plasma is replaced into the patients blood at an equal rate. The extracorporeal circuit only is anticoagulated. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Convection The movement of fluid across a semi-permeable membrane creating solute drag. As fluid is pulled across the membrane, some plasma and other soluble components dissolved in the fluid are taken with it. Plasma, small, middle, and large molecules are removed. Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.

Primary Indications Plasma replacement Plasma supplementation Individual Clinical Presentations Regional Citrate Anticoagulation is available Produced in partnership with The Royal London Hospital Copyright ©2015 NIKKISO Co., LTD. All rights reserved.