Some early Trends in Immunology Michelle Doherty, Morag J. Robertson  Trends in Immunology  Volume 25, Issue 12, Pages 623-631 (December 2004) DOI: 10.1016/j.it.2004.10.008 Copyright © 2004 Elsevier Ltd Terms and Conditions

Figure 1 Timeline through the early development of immunology. Discoveries impacting on the immune system found prior to the 20th century. Trends in Immunology 2004 25, 623-631DOI: (10.1016/j.it.2004.10.008) Copyright © 2004 Elsevier Ltd Terms and Conditions

Figure 2 Timeline of selected immunological developments and discoveries between 1900 and 1959. Abbreviations: Ab, antibody; Ags, antigens; HLAs, human leukocyte antigens; IFN, interferon; IRs, immune responses; Rh, Rhesus. Trends in Immunology 2004 25, 623-631DOI: (10.1016/j.it.2004.10.008) Copyright © 2004 Elsevier Ltd Terms and Conditions

Figure 3 Timeline of selected immunological developments and discoveries between 1960 and 1979. Asterisk (*) represents Lafferty and Cunningham's model. Abbreviations: Ab, antibody; Ag, antigen; IL-2, interleukin-2; IRs, immune responses; mAbs, monoclonal Abs; MLC, mixed lymphocyte culture. Trends in Immunology 2004 25, 623-631DOI: (10.1016/j.it.2004.10.008) Copyright © 2004 Elsevier Ltd Terms and Conditions

Figure 4 Timeline of selected immunological developments and discoveries between 1980 and today. Abbreviations: APCs, antigen-presenting cells; DCs, dendritic cells; HO-1, heme oxygenase-1; IL-8, interleukin-8; IL-1R, IL-1 receptor; IRs, immune responses; ITAMs, immunoreceptor tyrosine-based activation molecules; LPS, lipopolysaccharide; PRRs, pattern recognition receptors; RAG, recombination activating gene; R, receptor; SCID, severe combined immunodeficiency; TCR, T-cell receptor; TLRs, Toll-like receptors. Trends in Immunology 2004 25, 623-631DOI: (10.1016/j.it.2004.10.008) Copyright © 2004 Elsevier Ltd Terms and Conditions