Precision Medicine A New Era Hazem Assi American University of Beirut

and help physicians to apply more effective treatments What do we mean? Precision Medicine and Precision Oncology are the terms we use to describe: Advanced diagnostic profiling Therapeutic interventions tailored to suit Outcomes followed up Learnings shared dynamically Precision Medicine Using Advanced Diagnostic Profiling we identify how each patient cancer differs at the molecular level and help physicians to apply more effective treatments 2 2

Evidence Based Medicine Precision Medicine New fast high fidelity learning loops are needed to accelerate access to better care Intervention Outcome Tracking Guidelines Treatment Pathways Advanced Diagnostics Invent Trial Register Reimburse Adopt Guidelines Registries Phase 4 Studies Pharmacovigilance 3 3

Patient Centric Approach Patient A Drug Patient A Patient B Patient C Drug A Drug B Drug C THE FUTURE 4

to insufficient intervention to excessive intervention Investing In Precision Medicine Optimizes Clinical And Financial Outcomes Waste due to insufficient intervention Waste due to excessive intervention Outcome We find the people within a group that are most likely to respond to targeted therapy, thereby eliminating waste from either insufficient or excessive intervention. Insufficient Intervention: Patient receives a false negative result due to less sensitive testing and does not receive the benefit of associated targeted therapy Excessive Intervention: Patient received a targeted agent without a molecular diagnostic testing that would indicate the appropriateness of the therapy Insufficient Intervention Excessive Intervention Optimal Intervention LB/FMI/1710/0007