A B D C Total adiponectin (μg/ml ) Hb ( g / dl ) r = p = 0.003

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A B D C Total adiponectin (μg/ml ) Hb ( g / dl ) r = -0.349 p = 0.003 10 20 30 40 7 8 9 11 12 13 14 Total adiponectin (μg/ml ) Hb ( g / dl ) r = -0.349 p = 0.003 10 20 30 40 1 1.5 2 2.5 3 3.5 Total adiponectin (μg/ml ) log BNP ( pg / ml ) r = 0.440 p < 0.001 A B 10 20 30 1 1.5 2 2.5 3 3.5 log BNP ( pg / ml ) HMW adiponectin (μg/ml ) r = 0.400 p = 0.001 C 10 20 30 7 8 9 11 12 13 14 Hb ( g / dl ) HMW adiponectin (μg/ml ) r = -0.319 p = 0.007 D

Systolic blood pressure, mmHg 149.7 ± 19.6 149.5 ± 18.0 150.0 ± 20.6 Table 1.Demographic and clinical characteristics of the study population total male female p value Number 70 30 40 Age, years 65.2 ± 8.6 65.7 ± 8.6 64.5 ± 8.7 0.682 duration of HD, months 67.5 (30.0, 132.0) 55.5 (29.5, 121.5) 81.0 (43.5, 148.5) 0.250 BMI, kg/ ㎡ 20.4 ± 2.6 21.0 ± 2.0 19.9 ± 3.0 0.068 Systolic blood pressure, mmHg 149.7 ± 19.6 149.5 ± 18.0 150.0 ± 20.6 0.956 Diastolic blood pressure, mmHg 73.9 ± 9.4 75.8 ± 9.3 72.4 ± 9.2 0.134 Total cholesterol, mg/dl 168.5 ± 32.4 150.0 ± 25.9 182.4 ± 29.3 < 0.001 Triglycerides, mg/dl 93.5 (74.0, 119.8) 96.5 (73.0, 132.8) 91.0 (72.5, 116.8) 0.687 HDL cholesterol, mg/dl 45.0 ± 15.5 38.3 ± 12.6 50.1 ± 15.3 0.001 LDL cholesterol, mg/dl 97.5 ± 26.4 86.6 ± 22.7 105.1 ± 25.7 0.002 Albumin, g/dl 3.9 ± 0.4 0.895 Hemoglobin, g/dl 10.4 ± 1.0 0.406 HOMA-IR 1.48 (0.99, 1.87) 1.46 (1.00, 2.00) 1.48 (0.98, 1.85) 0.934 High-sensitive CRP, mg/dl 0.94 (0.35, 3.27 ) 1.60 (0.40, 4.17) 0.63 (0.32, 1.40 ) 0.050 BNP, pg/ml 258.6 (88.3, 306.8) 118.8 (75.4, 260.3) 224.1 (90.7, 356.1) 0.240 EF, % 67.7 ± 7.9 66.1 ± 9.8 68.9 ± 6.0 0.163 LVMI, g/ 122.1 ± 34.7 122.8 ± 37.9 121.7 ± 32.5 0.899 Total adiponectin, ?g/mL 14.4 ± 7.0 10.5 ± 5.0 16.8 ± 7.1 HMW adiponectin, ?g/ml 8.4 ± 5.4 5.1 ± 3.2 10.5 ± 5.6 HMW/Total adiponectin ratio 0.53 ± 0.12 0.45 ± 0.10 0.59 ± 0.10 DM (n; %) 18 (25.7) 10 (33.3) 8 (19.0) NS ACEIs/ARBs therapy (n; %) 16 (22.9) 7 (23.3) 9 (21.4) Data are shown as mean ± SD or median (range). BMI = body mass indexes; HOMA-IR = homeostasis model assessment of insulin resistance; hsCRP = high sensitive C-reactive protein; BNP = B-type natriuretic peptide; EF = ejection fraction; LVMI = left ventricular mass index; HMW = high molecular weight; ACEIs/ARBs = angiotensin converting enzyme inhibitors/ angiotensin II receptor blockers

BMI = body mass indexes; HOMA-IR = homeostasis model assessment of insulin resistance; hsCRP = high sensitive C-reactive protein; BNP = B-type natriuretic peptide; EF = ejection fraction, LVMI = left ventricular mass index;

Table3. Forward stepwise multiple regression analysis of dependent variable Total-Ad HMW-Ad Variables ｐ HDL-C 0.394 0.000 0.356 Hb -0.219 0.010 -0.180 0.034 log BNP 0.240 0.003 0.200 0.014 BMI -0.235 0.009 -0.270 sex 0.237 0.004 0.289 0.001 Independent variables tested include age and sex, as well as parameters showing a significant relationship in univariate analysis. β β