Mechanisms of Pulmonary Hypertension Related to Ventricular Septal Defect in Congenital Heart Disease Xiangbin Pan, MD, Zhe Zheng, MD, Shengshou Hu,

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Presentation transcript:

Mechanisms of Pulmonary Hypertension Related to Ventricular Septal Defect in Congenital Heart Disease Xiangbin Pan, MD, Zhe Zheng, MD, Shengshou Hu, MD, Shoujun Li, MD, Yingjie Wei, PhD, Yajuan Zhang, MD, Xiansheng Cheng, MD, Kai Ma, MD The Annals of Thoracic Surgery Volume 92, Issue 6, Pages 2215-2220 (December 2011) DOI: 10.1016/j.athoracsur.2011.07.051 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Elastic fiber and hematoxylin and eosin (H & E) staining. (A) H & E, ventricular septal defect (VSD)-alone group, ×400. (B) H & E, Transposition of the great arteries (TGA) + VSD group, ×400. (C) Elastic fiber staining, VSD-alone group, ×400. (D) Elastic fiber staining, TGA + VSD group, ×400. The Annals of Thoracic Surgery 2011 92, 2215-2220DOI: (10.1016/j.athoracsur.2011.07.051) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Matrix metalloproteinase 2 (MMP-2) and endothelial nitrous oxide synthase (eNOS) staining. (A) MMP-2, VSD-alone group, ×400. (B) MMP-2, transposition of the great arteries (TGA) + ventricular septal defect (VSD) group, ×400. (C) eNOS, VSD-alone group, ×400. (D) eNOS, TGA + VSD group, ×400. The Annals of Thoracic Surgery 2011 92, 2215-2220DOI: (10.1016/j.athoracsur.2011.07.051) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions