Elliott P, et al. JAMA 2009;302:37-48.

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Elliott P, et al. JAMA 2009;302:37-48

Manhattan Plot of Results From the Combined Analysis of Genome-Wide Association Data Elliott P, et al. JAMA 2009;302:37-48

Relationships Between Most Associated SNPs in the 5 Genetic Loci Associated With CRP Levels and Cardiovascular Risk Factors in Replication Sample (LOLIPOP, n = 13615) From Regression Analyses Adjusted for Age, Sex, and Ethnic Group Under an Additive Genetic Modela Elliott P, et al. JAMA 2009;302:37-48

Results of Mendelian Randomization Experiment of rs7553007 in the CRP Locus (Present Study) With rs1130864 and rs1205 From Published Studies Numbers totaled 28 112 cases with coronary heart disease and 100 823 controls. Effects are given as odds ratios (ORs) and 95% confidence intervals (CIs) per 20% lower C-reactive protein (CRP) level. E indicates European; IA, Indian Asian; SNP, single-nucleotide polymorphism. Elliott P, et al. JAMA 2009;302:37-48

Associations of SNPs rs1130864 and rs1205 With CRP Levels, CRP Levels With CHD, and SNPs With CHD Prospective studies were included that reported all 3 analyses. CHD indicates coronary heart disease; CI, confidence interval; CRP, C-reactive protein; OR, odds ratio; SNPs, single-nucleotide polymorphisms. Prospective studies were included that reported all 3 analyses. CHD indicates coronary heart disease; CI, confidence interval; CRP, C-reactive protein; OR, odds ratio; SNPs, single-nucleotide polymorphisms. Elliott P, et al. JAMA 2009;302:37-48

Meta-analysis of the Relationship of CRP Levels With CHD From Prospective Observational Studies Prospective studies were included that reported all 3 analyses. CHD indicates coronary heart disease; CI, confidence interval; CRP, C-reactive protein; OR, odds ratio; SNPs, single-nucleotide polymorphisms. Elliott P, et al. JAMA 2009;302:37-48

Associations of SNPs in LEPR (rs6700896), IL6R (rs4537545), and HNF1A (rs1183910) Loci and APOE-CI-CII (rs4420638) Cluster in the Genetic Association Study With CHD Prospective studies were included that reported all 3 analyses. CHD indicates coronary heart disease; CI, confidence interval; CRP, C-reactive protein; OR, odds ratio; SNPs, single-nucleotide polymorphisms. Elliott P, et al. JAMA 2009;302:37-48