Safety and efficacy of landiolol hydrochloride for prevention of atrial fibrillation after cardiac surgery in patients with left ventricular dysfunction:

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Presentation transcript:

Safety and efficacy of landiolol hydrochloride for prevention of atrial fibrillation after cardiac surgery in patients with left ventricular dysfunction: Prevention of Atrial Fibrillation After Cardiac Surgery With Landiolol Hydrochloride for Left Ventricular Dysfunction (PLATON) trial Akira Sezai, MD, PhD, Shunji Osaka, MD, PhD, Hiroko Yaoita, MD, Yusuke Ishii, MD, Munehito Arimoto, MD, Hiroaki Hata, MD, PhD, Motomi Shiono, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 150, Issue 4, Pages 957-964 (October 2015) DOI: 10.1016/j.jtcvs.2015.07.003 Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Changes in systolic blood pressure (sBP) and diastolic blood pressure (dBP) and in heart rate (HR). Pre, Preoperative; ICU, intensive care unit; D, postoperative day; W, postoperative week. The Journal of Thoracic and Cardiovascular Surgery 2015 150, 957-964DOI: (10.1016/j.jtcvs.2015.07.003) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Changes in the ischemic biomarkers creatine kinase isoenzyme MB (CPK-MB), troponin I, and human heart fatty acid–binding protein (H-FABP). ICU, Intensive care unit; D, postoperative day. The Journal of Thoracic and Cardiovascular Surgery 2015 150, 957-964DOI: (10.1016/j.jtcvs.2015.07.003) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Occurrence of postoperative atrial fibrillation. The Journal of Thoracic and Cardiovascular Surgery 2015 150, 957-964DOI: (10.1016/j.jtcvs.2015.07.003) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Changes in highly sensitive C-reactive protein (hs-CRP) and brain natriuretic peptide (BNP). Pre, Preoperative; ICU, intensive care unit; D, postoperative day; W, postoperative week, M, postoperative month. The Journal of Thoracic and Cardiovascular Surgery 2015 150, 957-964DOI: (10.1016/j.jtcvs.2015.07.003) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Postoperative atrial fibrillation was significantly lower in the landiolol group. The Journal of Thoracic and Cardiovascular Surgery 2015 150, 957-964DOI: (10.1016/j.jtcvs.2015.07.003) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions